461706-35-4

Usage

Uses

Used in Organic Synthesis:
5(4H)-Oxazolone, 4-[(2-broMophenyl)Methylene]-2-Methylis utilized as a key component in organic synthesis, where its reactivity and ability to form hydrogen bonds contribute to the creation of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 5(4H)-Oxazolone, 4-[(2-broMophenyl)Methylene]-2-Methylserves as a reactant in chemical reactions that are crucial for the development of new drugs. Its unique structure allows it to be a versatile building block in medicinal chemistry.
Used in Drug Development:
5(4H)-Oxazolone, 4-[(2-broMophenyl)Methylene]-2-Methylis employed in the development of new drugs due to its potential to enhance the properties of pharmaceutical compounds. Its incorporation into drug molecules can lead to improved efficacy and selectivity in targeting specific biological pathways.
Used in Medicinal Chemistry:
5(4H)-Oxazolone, 4-[(2-broMophenyl)Methylene]-2-Methylhas potential applications in the field of medicinal chemistry, where its unique chemical structure can be leveraged to design and synthesize novel therapeutic agents with specific pharmacological properties.

Upstream product

• 6630-33-7 ortho-bromobenzaldehyde 
• 543-24-8 N-acetylglycine 

Downstream Products

• 194724-02-2 (S)-methyl 2-acetamido-3-(2-bromophenyl)propanoate 
• 863487-03-0 methyl α-acetamido-β-(2-bromophenyl)-acrylate 
• 164461-16-9 methyl (R)-2-acetamido-3-(2-bromophenyl)propanoate 

Relevant academic research and scientific papers

Concise synthesis and applications of enantiopure spirobiphenoxasilin-diol and its related chiral ligands

The development of chiral architectures for chiral ligand and catalyst discovery is essential for asymmetric catalysis. Herein, we report the concise synthesis of a Si-centered spirocyclic skeleton, spirobiphenoxasilin-diol (SPOSiOL), and its derived chiral ligands. Using the chemical resolution method, the optical SPOSiOL could be obtained in high yield on a gram scale. Preliminary studies indicated that this ligand scaffold has great potential in transition metal-catalyzed asymmetric reactions. This finding further highlights that the Si-centered spirocyclic scaffolds are of great value in asymmetric catalysis. This journal is

Silver-Promoted Direct Phosphorylation of Bulky C(sp2)-H Bond to Build Fully Substituted β-Phosphonodehydroamino Acids

A general and practical cross-dehydrogenative coupling protocol between readily available trisubstituted α,β-dehydro α-amino carboxylic esters and H-phosphites is described. This C(sp2)-H phosphorylation reaction proceeds with absolute Z-selectivity promoted by silver salt in a radical relay manner. The bulky tetrasubstituted β-phosphonodehydroamino acids were obtained in grams and added new modules to the toolkit for peptide modifications.

Construction of Chiral-Fused Tricyclic γ-Lactams via a trans-Perhydroindolic Acid-Catalyzed Asymmetric Domino Reaction

An asymmetric domino reaction was developed utilizing readily available cyclic α-dehydroamino ketones and aldehydes, which when subjected a 2-iodoxybenzoic acid (IBX)-mediated oxidation gives pyrrolidinone-containing tricyclic derivatives. trans-Perhydroi

Cation-triggered switchable asymmetric catalysis with chiral aza-crownphos

An aza-crown ether, modified phosphoramidite ligand, has been designed and synthesized. The ON/OFF reversible switch of catalytic activity for its rhodium catalyst was thoroughly investigated in the asymmetric hydrogenation of dehydroamino acid esters modulated by host-guest interactions. In the OFF state, the catalyst is almost inactive (less than 1% conversion) because of the formation of an intermolecular sandwich complex by two aza-crown ether moities and the cationic rhodium metal center. In using alkali-metal-cations as the trigger, the catalytic activity was turned ON and consequently resulted in full conversions and excellent enantioselectivities (up to 98% ee).

Oxazolone-based photoswitches: Synthesis and properties

The synthesis, photophysics and photochemistry of a family of molecular switches inspired by the green fluorescent protein (GFP) chromophore is presented. These compounds can be synthesized in one step and good yields, their photophysical properties may b

Benzylidene-oxazolones as photoswitches: Photochemistry and theoretical calculations

The photophysics and photochemistry of a family of compounds proposed as efficient molecular photoswitches is presented. The effect of different light sources, substituents and solvents in the photostationary state has been explored. A detailed mechanisti