461719-99-3

Upstream product

• 402-67-5 3-fluoro-1-nitrobenzene 
• 54054-85-2 1-(3-nitrophenyl)piperazine 
• 461719-98-2 2-benzyloxycarbonylamino-5-[4-(3-nitro-phenyl)-piperazin-1-yl]-5-oxo-pentanoic acid tert-butyl ester 

Downstream Products

• 461720-00-3 (2S)-2-benzyloxycarbonylamino-5-[4-[3-[1,3-bis(tertbutoxycarbonyl)hexahydropyrimidin-2-ylidene]aminophenyl]piperazin-1-yl]-5-oxopentanoic acid tert-butyl ester 

Relevant academic research and scientific papers

Discovery of a potent and selective αvβ3 integrin antagonist with strong inhibitory activity against neointima formation in rat balloon injury model

A new series of phenylpiperazine-based derivatives with strong antagonistic activity for αvβ3 integrin were synthesized. Of these derivatives, the fluorine-substituted compound 8 showed strong inhibitory activity and high selectivity for αvβ 3 integrin receptor (IC50=0.055nM). In vivo evaluation of the antistenotic effects of 8 indicated that this compound significantly inhibits neointima formation in rat balloon injury model.