461720-00-3

Upstream product

• 173300-85-1 N,N'-(di-tert-butoxycarbonyl)-3,4,5,6-tetrahydro-1H-2-pyrimidinethione 
• 461719-99-3 5-[4-(3-amino-phenyl)-piperazin-1-yl]-2-benzyloxycarbonylamino-5-oxo-pentanoic acid tert-butyl ester 
• 402-67-5 3-fluoro-1-nitrobenzene 
• 54054-85-2 1-(3-nitrophenyl)piperazine 
• 461719-98-2 2-benzyloxycarbonylamino-5-[4-(3-nitro-phenyl)-piperazin-1-yl]-5-oxo-pentanoic acid tert-butyl ester 

Relevant academic research and scientific papers

Discovery of a potent and selective αvβ3 integrin antagonist with strong inhibitory activity against neointima formation in rat balloon injury model

A new series of phenylpiperazine-based derivatives with strong antagonistic activity for αvβ3 integrin were synthesized. Of these derivatives, the fluorine-substituted compound 8 showed strong inhibitory activity and high selectivity for αvβ 3 integrin receptor (IC50=0.055nM). In vivo evaluation of the antistenotic effects of 8 indicated that this compound significantly inhibits neointima formation in rat balloon injury model.

ARYL-SUBSTITUTED ALICYCLIC COMPOUND AND MEDICAL COMPOSITION COMPRISING THE SAME

An aryl-substituted alicyclic compound of the formula (I): wherein U is 1,4,5,6-tetrahydropyrimidin-2-yl, etc., A is phenylene, etc., B is piperidine-1,4-diyl, etc., Z is -CONH-, etc., R3 is hydrogen, etc., R5 is hydrogen, aryl, etc.