46192-58-9Relevant academic research and scientific papers
New antibacterial diazotized derivatives of 5-amino azaheterocycles
Gondal, Humaira Yasmeen,Ali, Muhammad
, p. 1343 - 1348 (2014/01/06)
Six new diazotized derivatives of pharmacologically important azaheterocycles (2a-d, 4a-b) were prepared from their corresponding 5-amino benzimidazoles (1a-d) and benzimidazolones (3a-b). All new compounds have been characterized on the basis of their IR, NMR and Mass spectral data. Antibacterial activity of these compounds is also been reported.
New antibacterial peptide analogs of 5-Aminobenzimidazoles
Gondal, Humaira Y.,Mashooda,Ali, Muhammad
experimental part, p. 650 - 655 (2011/10/08)
Three new peptide analogs 5a-c were obtained through coupling of 5-Amino benzimidazoles 2a-c with L-phenylalanine. For the purpose α-amino group was blocked with phthalic anhydride and activation of α-carboxy group of phenylalanine was carried out by preparing phthaloyl-L-phenylalanyl chloride 4. After developing a successful peptide linkage, the phthaloyl group was removed by treating 5a-c with hydrazine hydrate to get free peptides 6a-c, purified through a column of Amberlite (IR-4B). All of these compounds 2a-c and 5,6a-c have been characterized on the basis of their IR, 1H NMR and EIMS analyses. Antibacterial activity of these compounds is also been reported.
