462-27-1Relevant academic research and scientific papers
Exploration of potential prodrug approach of the bis-thiazolium salts T3 and T4 for orally delivered antimalarials
Caldarelli, Sergio A.,Boisbrun, Michel,Alarcon, Karine,Hamze, Abdallah,Ouattara, Mahama,Salom-Roig, Xavier,Maynadier, Marjorie,Wein, Sharon,Peyrottes, Suzanne,Pellet, Alain,Calas, Michle,Vial, Henri
supporting information; experimental part, p. 3953 - 3956 (2010/09/03)
We report here the synthesis and biological evaluation of a series of 37 compounds as precursors of potent antimalarial bis-thiazolium salts (T3 and T4). These prodrugs were either thioester, thiocarbonate or thiocarbamate type and were synthesized in one
1-Aziridine carboxylic acid derivatives with immunostimulant activity
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, (2008/06/13)
2-Substituted-1-aziridine-carboxylic acid esters exhibiting immuno-stimulant activity and of the formula STR1 wherein X is a carbamoyl or alkoxycarbonyl radical, and R1 is an aliphatic hydrocarbon radical optionally substituted by halogen, alkoxy, amino, carbamoyloxy, cycloalkyl, hydroxyl, an imido or heterocyclic radical, cycloalkyl; or aryl, aralkyl, aryloxyalkyl or arylthioalkyl wherein the aryl moiety is optionally substituted by halogen, alkyl, alkoxy, hydroxyl, amino, nitro, cyano, acyl, carbalkoxy, thioalkyl, alkylsulphonyl, phenyl or trifluoromethyl. Counterparts where X is --CN and R1 is as above, except for ethyl, are also new.
Herbicidal fluorinated carbonates
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, (2008/06/13)
Fluorinated carbonates are described which are useful as miticides. These carbonates often possess herbicidal, insecticidal, and/or fungicidal properties. Examples of the fluorinated carbonates are 2',4'-dinitro-6'-sec-butylphenyl-2,2,2-trifluoroethyl carbonate; 2',4'-dinitro-6'-sec-butylphenyl-2,2,3,3-tetrafluoropropyl carbonate and 2',4'-dinitro-6'-cyclohexylphenyl 2,2,3,3-tetrafluoropropyl carbonate.
