46206-74-0Relevant academic research and scientific papers
Design, synthesis, and evaluation of simple phenol amides as ERRγ agonists
Lin, Hua,Doebelin, Christelle,Patouret, Rémi,Garcia-Ordonez, Ruben D.,Ra Chang, Mi,Dharmarajan, Venkatasubramanian,Bayona, Claudia Ruiz,Cameron, Michael D.,Griffin, Patrick R.,Kamenecka, Theodore M.
, p. 1313 - 1319 (2018/03/21)
Herein we report the design and synthesis of a series of simple phenol amide ERRγ agonists based on a hydrazone lead molecule. Our structure activity relationship studies in this series revealed the phenol portion of the molecule to be required for activity. Attempts to replace the hydrazone with more suitable chemotypes led to a simple amide as a viable alternative. Differential hydrogen-deuterium exchange experiments were used to help understand the structural basis for binding to ERRγ and aid in the development of more potent ligands.
NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE
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Page/Page column 73, (2009/10/01)
The present invention relates to piperidine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
