85292-45-1

Basic information

• Product Name: 4-(5-PHENYL-1,3,4-OXADIAZOL-2-YL)BENZOIC ACID
• Synonyms: Benzoicacid, p-5-phenyl-1,3,4-oxadiazol-2-yl- (6CI)
• CAS NO: 85292-45-1
• Molecular Formula: C₁₅H₁₀N₂O₃
• Molecular Weight: 266.26
• Mol File: 85292-45-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 484.3°C at 760 mmHg
• Flash Point: 246.7°C
• Appearance: /
• Density: 1.319g/cm³
• Vapor Pressure: 3.43E-10mmHg at 25°C
• Refractive Index: 1.619
• CAS DataBase Reference: 4-(5-PHENYL-1,3,4-OXADIAZOL-2-YL)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-PHENYL-1,3,4-OXADIAZOL-2-YL)BENZOIC ACID(85292-45-1)
• EPA Substance Registry System: 4-(5-PHENYL-1,3,4-OXADIAZOL-2-YL)BENZOIC ACID(85292-45-1)

Safety Data

• Hazardous Substances Data: 85292-45-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H10N2O3/c18-15(19)12-8-6-11(7-9-12)14-17-16-13(20-14)10-4-2-1-3-5-10/h1-9H,(H,18,19)

Upstream product

• 85292-39-3 methyl 4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzoate 
• 66395-10-6 4-(N'-Benzoyl-hydrazinocarbonyl)-benzoic acid methyl ester 
• 7377-26-6 4-Methoxycarbonylbenzoyl chloride 
• 613-94-5 benzoic acid hydrazide 
• 119072-55-8 tert-butylisonitrile 
• 619-58-9 4-iodobenzoic acid 
• 100-52-7 benzaldehyde 
• 46206-74-0 4-(hydrazinecarbonyl)benzoic acid 
• 98-88-4 benzoyl chloride 
• 82544-82-9 5-tetrazole 
• 109411-44-1 N'-benzoyl-terephthalohydrazidic acid 

Downstream Products

• 93-89-0 benzoic acid ethyl ester 
• 636-09-9 diethyl terephthalate 
• 1246770-52-4 ((R)-N-(1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide) 

Relevant articles and documents

Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents

To discover antifungal compounds with broad-spectrum and stable metabolism, a series of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives was designed and synthesized. Compounds A30-A34 exhibited excellent broad-spectrum antifungal activity against Candida albicans with MIC values in the range of 0.03–0.5 μg/mL, and against Cryptococcus neoformans and Aspergillus fumigatus with MIC values in the range of 0.25–2 μg/mL. In addition, compounds A31 and A33 showed high metabolic stability in human liver microsomes in vitro, with the half-life of 80.5 min and 69.4 min, respectively. Moreover, compounds A31 and A33 showed weak or almost no inhibitory effect on the CYP3A4 and CYP2D6. The pharmacokinetic evaluation in SD rats showed that compound A31 had suitable pharmacokinetic properties and was worthy of further study.

DNA-Encoded Libraries: Hydrazide as a Pluripotent Precursor for On-DNA Synthesis of Various Azole Derivatives

DNA-encoded combinatorial chemical library (DEL) technology, an approach that combines the power of genetics and chemistry, has emerged as an invaluable tool in drug discovery. Skeletal diversity plays a fundamental importance in DEL applications, and relies heavily on novel DNA-compatible chemical reactions. We report herein a phylogenic chemical transformation strategy using DNA-conjugated benzoyl hydrazine as a common versatile precursor in azole chemical expansion of DELs. DNA-compatible reactions deriving from the common benzoyl hydrazine precursor showed excellent functional group tolerance with exceptional efficiency in the synthesis of various azoles, including oxadiazoles, thiadiazoles, and triazoles, under mild reaction conditions. The phylogenic chemical transformation strategy provides DELs a facile way to expand into various unique chemical spaces with privileged scaffolds and pharmacophores.

FUNCTION REGULATOR FOR RETINOID RELATIVE RECEPTOR

The present invention provides a retinoid-related receptor (except retinoic acid receptors) function regulatin agent comprising a compound represented by the formula: wherein one of R1 and R2 is an optionally substituted monocyclic a