462100-53-4Relevant articles and documents
Synthesis of chiral pilocarpine analogues via a C-8 ketone intermediate.
Holden, Kenneth G,Mattson, Matthew N,Cha, Kyung Hoi,Rapoport, Henry
, p. 5913 - 5918 (2007/10/03)
The synthesis of a chiral pilocarpine analogue 3 in which the lactone ring is replaced by an oxazolidinone and the bridging methylene group is in the ketone oxidation state has been accomplished. The utility of this compound as a key intermediate for the preparation of more complex structures was demonstrated by its reduction to two alcohol epimers and its reaction with a methylene ylide.