71759-88-1

Usage

Uses

Used in Pharmaceutical Industry:
5-IODO-1-METHYL-1H-IMIDAZOLE is used as an active pharmaceutical ingredient for the development of medications, leveraging its chemical properties to target specific biological processes and conditions.
Used in Chemical Research:
5-IODO-1-METHYL-1H-IMIDAZOLE is used as a research compound in the field of organic chemistry, allowing scientists to study its reactivity, structure, and potential applications in the synthesis of other compounds.
Used in Material Science:
5-IODO-1-METHYL-1H-IMIDAZOLE is used as a component in the development of new materials, such as sensors or catalysts, due to its unique chemical properties and potential interactions with other molecules.
Used in Diagnostic Applications:
5-IODO-1-METHYL-1H-IMIDAZOLE is used as a diagnostic agent in medical imaging, where its chemical properties may enhance the visibility of specific tissues or structures within the body.
Used in Environmental Applications:
5-IODO-1-METHYL-1H-IMIDAZOLE is used in environmental monitoring and remediation efforts, potentially serving as a tracer or indicator for the presence of certain contaminants or pollutants.

Upstream product

• 86026-81-5 2,5-diiodo-1-methyl-1H-imidazole 
• 71759-89-2 4-iodoimidazole 
• 74-88-4 methyl iodide 
• 333-27-7 methyl trifluoromethanesulfonate 
• 71759-89-2 5-iodo-1H-imidazole 
• 592554-93-3 C₂₃H₂₀IN₂⁽¹⁺⁾*I^(1-) 
• 616-47-7 1-methyl-1H-imidazole 
• 420-37-1 trimethoxonium tetrafluoroborate 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 111600-95-4 1-methyl-5-phenylethynyl-1H-imidazole 
• 108905-60-8 (E)-1-methyl -5-styryl-1H-imidazole 
• 462100-53-4 (R)-3-ethyl-4-(1'-methyl-5'-imidazolylcarbonyl)-2-oxazolidinone 
• 222978-26-9 2-Fluoro-4-[hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile 
• 1400287-23-1 2-chloro-4-(1-methyl-1H-imidazol-5-yl)aniline 
• 616-47-7 1-methyl-1H-imidazole 
• 1310826-23-3 methyl [5-(4-chlorophenyl)-3-methyl-1-(1-methyl-1H-imidazol-5-yl)-1H-pyrazol-4-yl]acetate 
• 450844-55-0 (S)-(4-cyanophenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-acetic acid (1R,2S,5R)-menthyl ester 
• 39021-62-0 1-methylimidazole-5-carbaldehyde 
• 71759-92-7 5-ethynyl-1-methyl-1H-imidazole 
• 1599529-23-3 (3-benzyl-2,4-dimethylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanone 
• 1350323-92-0 3-[(1S)-1-(2-Chloro-3-fluoro-6-methoxyphenyl)ethyl]-5-(1-methyl-1H-imidazol-5-yl)-1H-pyrrolo[2,3-b]pyridine 

Relevant academic research and scientific papers

PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS

The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: (I), where R1, R2, R3, R3', R4, R5, X1, X2, X3, X4, and n are described herein.

Ionic liquid iodinating reagent for mild and efficient iodination of aromatic and heteroaromatic amines and terminal alkynes

Hexamethylene bis(N-methylimidazolium) bis(dichloroiodate) (HMBMIBDCI), an ionic liquid iodinating reagent, have been prepared and characterized. Its ability to perform iodination reactions with a variety of substrates has been explored. In general, iodination reactions of aromatic and heteroaromatic amines proceed with good yields in the absence of solvent. Reactions of terminal alkynes in the presence of 1,8-diazabicyclo [5.4.O] undec-7-ene and tetrahydrofuran have been investigated as well.

Development of a regioselective N-methylation of (benz)imidazoles providing the more sterically hindered isomer

An efficient and highly regioselective N-methylation of (NH)-(benz)imidazoles furnishing the sterically more hindered, less stable, and usually minor regioisomer has been developed. The methodology involves very mild reaction conditions and tolerates a wide range of functional groups.

Novel farnesyl protein transferase inhibitors as antitumor agents

Disclosed are novel tricyclic compounds represented by the formula (1.0): and a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising compounds of formula 1.0. Also disclosed are methods of treating cancer using the compounds of formula 1.0.

A convenient synthesis of 1,4-disubstituted imidazoles

An efficient method for the regioselective protection of 4-alkyl-, 4-iodo, 4-vinylimidazoles has been developed via an alkylation-isomerization sequence with various imidazole-protecting groups. The initially formed mixture of 4/5-alkyl-, 4/5-iodo, and 4/5-vinylimidazoles are isomerized to the corresponding 4-isomers on treatment of a DMF solution with a small amount of RX and heating at 75°C.

Synthesis of chiral pilocarpine analogues via a C-8 ketone intermediate.

The synthesis of a chiral pilocarpine analogue 3 in which the lactone ring is replaced by an oxazolidinone and the bridging methylene group is in the ketone oxidation state has been accomplished. The utility of this compound as a key intermediate for the preparation of more complex structures was demonstrated by its reduction to two alcohol epimers and its reaction with a methylene ylide.

An efficient route to 5-iodo-1-methylimidazole: Synthesis of xestomanzamine A

An efficient and practical route to C-5 functionalized N-methylated imidazoles is reported. 5-Iodo-1-methylimidazole was synthesized in four steps from imidazole, with complete regiospecificity, in 73% overall yield. The synthesis of xestomanzamine A, a marine natural product isolated in 1995 from an Okinawan sponge of Xestospongia sp., has been achieved using 5-iodo-1-methylimidazole in a modified Grignard reaction with a β-carboline ester moiety, in an overall yield of 59% based upon imidazole and 53% based upon tryptamine.

Metal-Halogen Exchange Reactions of Mono- and Poly-halogenoimidazoles

4(5)-Bromoimidazole gave a mixture of 4- and 5-bromo-1-methylimidazole on treatment with 1 or 2 mol equiv. of n-butyl-lithium in ether or THF under various reaction conditions followed by addition of dimethyl sulphate. 5-Iodo and 2,4,5-tribromo-1-methylim