71759-88-1Relevant articles and documents
PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS
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Paragraph 00394, (2017/06/12)
The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: (I), where R1, R2, R3, R3', R4, R5, X1, X2, X3, X4, and n are described herein.
Ionic liquid iodinating reagent for mild and efficient iodination of aromatic and heteroaromatic amines and terminal alkynes
Nouzarian, Mahboobe,Hosseinzadeh, Rahman,Golchoubian, Hamid
supporting information, p. 2913 - 2925 (2013/09/02)
Hexamethylene bis(N-methylimidazolium) bis(dichloroiodate) (HMBMIBDCI), an ionic liquid iodinating reagent, have been prepared and characterized. Its ability to perform iodination reactions with a variety of substrates has been explored. In general, iodination reactions of aromatic and heteroaromatic amines proceed with good yields in the absence of solvent. Reactions of terminal alkynes in the presence of 1,8-diazabicyclo [5.4.O] undec-7-ene and tetrahydrofuran have been investigated as well.
A convenient synthesis of 1,4-disubstituted imidazoles
He, Yong,Chen, Yingzhong,Du, Hongwang,Schmid, Lesley A.,Lovely, Carl J.
, p. 5529 - 5532 (2007/10/03)
An efficient method for the regioselective protection of 4-alkyl-, 4-iodo, 4-vinylimidazoles has been developed via an alkylation-isomerization sequence with various imidazole-protecting groups. The initially formed mixture of 4/5-alkyl-, 4/5-iodo, and 4/5-vinylimidazoles are isomerized to the corresponding 4-isomers on treatment of a DMF solution with a small amount of RX and heating at 75°C.