462125-47-9

Upstream product

• 26166-39-2 Ascochlorin 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 611217-61-9 3-acetoxy-4-chloro-6-(1,3-dioxolan-2-yl)-5-methyl-2-[(2E,4E)-3-methyl-5-((6R,7R,8R)-6,7,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-yl)-2,4-pentadienyl]phenyl acetate 
• 611217-63-1 3-acetoxy-4-chloro-6-(1,3-dioxolan-2-yl)-5-methyl-2-[(E)-2,3-epoxy-3-methyl-5-((6R,7R,8R)-6,7,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-yl)-2,4-pentadienyl]phenyl acetate 
• 38561-37-4 4-O-Acetylascochlorin 
• 748798-41-6 4-O-acetyl-ascochlorin dimethylacetal 

Relevant academic research and scientific papers

Process for preparing transcription factors and their use

The present invention has an object to develop novel compounds which are effective for the therapy of syndrome X, cancer, myxedema, vascular chronic inflammation and the like, and furthermore prevent/treat the restenosis caused in an artery expansion by a balloon or a stent and have the activity facilitating regenerative medicine by inhibiting rejection of own cells or tissues to be transplanted and the method for preparing the same. Novel acetal derivatives obtained by acylating the hydroxyl group at the 2-position of the orcylaldehyde which ascochlorin and its analogs have and thereafter bonding an alcohol to the aldehyde group in the presence of a basic catalyst are found to achieve the object.

Method for preparing novel transcription factors and use

The present invention has an object to develop novel compounds which are effective for the therapy of syndrome X, cancer, myxedema, vascular chronic inflammation and the like, and furthermore prevent/treat the restenosis caused in an artery expansion by a balloon or a stent and have the activity facilitating regenerative medicine by inhibiting rejection of own cells or tissues to be transplanted and the method for preparing the same. Novel acetal derivatives obtained by acylating the hydroxyl group at the 2-position of the orcylaldehyde which ascochlorin and its analogs have and thereafter bonding an alcohol to the aldehyde group in the presence of a basic catalyst are found to achieve the object.

NOVEL TRANSCRIPTIONAL FACTOR, PROCESS FOR PRODUCING THE SAME AND USE THEREOF

Ascochlorin or an analog or derivative thereof and a compound having a primary amino group are mixed and reacted with each other in the presence/absence of a basic catalyst to synthesize a novel imino compound. The novel imino compound thus synthesized is

MEDICINAL COMPOSITION FOR DIAGNOSIS, PREVENTION, OR THERAPY OF MULTIPLE RISK FACTOR SYNDROME

A preventive or therapeutic agent for multiple risk factor syndrome containing, as an active ingredient, one or more chemical compounds selected from the group consisting of ascochlorin, ascochlorin homologues, ascofuranone and ascofuranone homologues, ??

Ascochlorin derivatives as ligands for nuclear hormone receptors

Nuclear receptor family proteins are structurally related transcription factors activated by specific lipophilic compounds. Because they are activated by a variety of hormonal molecules, including retinoic acid, vitamin D, and steroid hormones, they are a