46230-70-0Relevant academic research and scientific papers
Mild and efficient synthesis of propargylamines by copper-catalyzed Mannich reaction
Bieber, Lothar W.,Da Silva, Margarete F.
, p. 8281 - 8283 (2007/10/03)
Terminal alkynes can be condensed with aqueous formaldehyde and primary or secondary amines to give secondary and tertiary propargylamines. The reaction is best carried out in DMSO under CuI catalysis. Terminal alkynes undergo mild and efficient aminomethylation with aqueous formaldehyde and secondary amines under CuI catalysis. In most cases high to nearly quantitative yields of tertiary propargylamines are obtained in DMSO solution at room temperature. Aromatic, aliphatic and silylated acetylenes as well as alkynols can be used. Primary amines are less reactive and satisfactory yields of secondary propargylamines are obtained only with phenylacetylene.
MANNICH AND GRIGNARD REACTION OF SOME N-(2-PROPYNYL) AZAHETEROCYCLES
Silhankova, Alexandra,Hoskovec, Michal,Liboska, Radek,Ferles, Miloslav
, p. 1067 - 1081 (2007/10/02)
1,4-Disubstituted butynes IV-VII were prepared by Mannich reaction of N-(2-propynyl) derivatives of 1,2,3,4-tetrahydroquinoline, 1,2,3,4-tetrahydroisoquinoline, piperidine and azacycloheptane with polyoxymethylene and another heterocyclic amines.Reaction of 3-(1-piperidinyl)-1-propynylmagnesium bromide or 3-(1-azacycloheptyl)-1-propynylmagnesium bromide afforded alcohols X-XIII.
HALOGENATION OF HETEROCYCLIC ACETYLENIC MONO- AND DIAMINES
Kurbanov, A. I.,Turgunov, E.,Sirlibaev, T. S.
, p. 1135 - 1137 (2007/10/02)
Cyclic acetylenic monoamines, synthesized by the decomposition of the corresponding acetylenic aminoalcohols, and diamines, obtained by the Mannich reaction, give the products of the monoaddition of the halogens at the triple bond in aqueous solutions of acids.
