46249-78-9

Basic information

• Product Name: Bicyclo[2.2.1]heptane-2-carboxylic acid, 4,7,7-trimethyl-3-oxo-, (1S,4S)-
• CAS NO: 46249-78-9
• Molecular Formula: C11H16O3
• Molecular Weight: 196.246
• Mol File: 46249-78-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Bicyclo[2.2.1]heptane-2-carboxylic acid, 4,7,7-trimethyl-3-oxo-, (1S,4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Bicyclo[2.2.1]heptane-2-carboxylic acid, 4,7,7-trimethyl-3-oxo-, (1S,4S)-(46249-78-9)
• EPA Substance Registry System: Bicyclo[2.2.1]heptane-2-carboxylic acid, 4,7,7-trimethyl-3-oxo-, (1S,4S)-(46249-78-9)

Safety Data

• Hazardous Substances Data: 46249-78-9(Hazardous Substances Data)

Upstream product

• 124-38-9 carbon dioxide 
• 736109-58-3 1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-one 
• 76-22-2 Camphor 
• 15719-64-9 methylammonium carbonate 
• 56-54-2 quinidine 

Downstream Products

• 129940-80-3 2-oxobornan-3-carbonyl chloride 
• 124-38-9 carbon dioxide 
• 76-22-2 Camphor 
• 928053-52-5 N'-(2,4-difluoro-phenyl)-N'-((1S,4S)-4,7,7-trimethyl-3-oxo-bicyclo[2.2.1]heptane-2-carbonyl)-hydrazinecarboxylic acid tert-butyl ester 
• 928053-36-5 (1S,4S)-4,7,7-trimethyl-3-oxo-bicyclo[2.2.1]heptane-2-carbonyl chloride 

Relevant articles and documents

Synthesis and local anesthetic activity of some derivatives of N,N-diethyl-2-(2-alkoxyphenylcarbamoyloxy)bornan-3-ylmethyl-ammonium chlorides

A series of 8 new esters of 2-alkoxyphenyl-carbamoic acid were synthesized and assayed for local anesthetic activity. All compounds were isolated as hydrochlorides and their structure was proved by 1H-NMR 13C-NMR and IR spectroscopy. The index of anesthetic activity in infiltration and surface anesthesia proved that all prepared compounds are significantly more active than the standard reference compounds, procaine and cocaine, respectively; it is tightly correlated with the length of the alkoxy group. It was found that there is a parabolic relationship between log activity and molecular lipophilicity (as measured by R(M)). Toxicity of all compounds is within acceptable limits.