462611-02-5

Basic information

• Product Name: 1-[2-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-3-methyl-butan-1-one
• Synonyms: 1-[2-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-3-methyl-butan-1-one
• CAS NO: 462611-02-5
• Molecular Weight: 322.52
• Mol File: 462611-02-5.mol

Chemical Properties

• CAS DataBase Reference: 1-[2-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-3-methyl-butan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-3-methyl-butan-1-one(462611-02-5)
• EPA Substance Registry System: 1-[2-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-3-methyl-butan-1-one(462611-02-5)

Safety Data

• Hazardous Substances Data: 462611-02-5(Hazardous Substances Data)

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 75-26-3 isopropyl bromide 
• 462610-98-6 1-(2-((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)ethan-1-one 

Downstream Products

• 193687-88-6 1-(2-hydroxy-4-methoxyphenyl)-3-methylbutan-1-one 

Relevant articles and documents

Synthesis and biological evaluation of some novel 4H-benzopyran-4-one derivatives as nonsteroidal antiestrogens

The preparation and characterization of some novel 2- and 3-substituted-7-methoxy-4H-1-benzopyran-4-one are presented. The synthesized compounds were evaluated for their uterotrophic, antiuterotrophic and antiimplantation activities in mature female albino rats. 3-Benzyl-7-methoxy-4H-1-benzopyran-4-one (14) showed the highest uterotrophic activity (87%) based on dry uterine weight gain. The antifertility activity, as assessed by the post-coital antiimplantation activity test, was of weak potency for most compounds (14-29%). Among the products, the 2-(4′-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one (19) exhibited the highest antiestrogenic activity of 65%. It also elicited 31% of the uterotrophic activity of estradiol.