462655-29-4Relevant academic research and scientific papers
Enantioselective synthesis of β-amino esters and its application to the synthesis of the enantiomers of the antidepressant Venlafaxine
Davies, Huw M. L.,Ni, Aiwu
, p. 3110 - 3112 (2008/09/20)
β-Amino esters are readily formed from the rhodium(ii) prolinate-catalyzed intermolecular C-H insertion between methyl aryldiazoacetates and a bis-silyl protected methylamine. The Royal Society of Chemistry 2006.
Catalytic enantioselective synthesis of β2-amino acids
Davies, Huw M. L.,Venkataramani, Chandrasekar
, p. 2197 - 2199 (2007/10/03)
A very direct approach for the synthesis of β-amino esters is provided by catalytic asymmetric C-H activation by means of carbenoid-induced C-H insertion (see scheme; Boc = butyloxycarbonyl; TFA = trifluoroacetic acid). The reactions described herein represent the first regioselective intermolecular C-H insertions occurring at a methyl site.
