46277-44-5Relevant academic research and scientific papers
Probing the in-air growth of large area of 3D functional structures into a 2D supramolecular nanoporous network
Brisse, Romain,Guianvarc'h, Dominique,Mansuy, Christelle,Sagan, Sandrine,Kreher, David,Sosa-Vargas, Lydia,Hamitouche, Lydia,Humblot, Vincent,Arfaoui, Imad,Labet, Vanessa,Paris, Céline,Petit, Christophe,Attias, André-Jean
, p. 10068 - 10071 (2018)
Surface-confined host-guest chemistry at the air/solid interface is used for trapping a functionalized 3D Zn-phthalocyanine complex into a 2D porous supramolecular template allowing the large area functionalization of an sp2-hybridized carbon-based substrate as evidenced by STM, resonance Raman spectroscopy, and water contact angle measurements.
Organoruthenium and osmium anticancer complexes bearing a maleimide functional group: Reactivity to cysteine, stability, and cytotoxicity
Moon, Sally,Hanif, Muhammad,Kubanik, Mario,Holtkamp, Hannah,S?hnel, Tilo,Jamieson, Stephen M. F.,Hartinger, Christian G.
, p. 231 - 236 (2015/01/30)
Targeted delivery provides a means to overcome the systemic toxicity of cancer chemotherapeutics. Maleimide functionalization of anticancer-active metal complexes allows their site-selective covalent conjugation to human serum albumin (HSA) to exploit passive targeting to the tumor site through the enhanced permeability and retention (EPR) effect. By incorporating the maleimide moiety in the monodentate N-donor coligands, a series of [MII(cym)X2] (M = Ru, Os; cym = η6-pcymene; X = Cl2, Br2, I2, oxalate) complexes was synthesized and characterized. The influence of the metal center, η6-arene, and leaving group X on the chemical and biological properties was studied. The compounds exhibited low stability in dimethyl sulfoxide (DMSO) but were more stable in the 5% aqueous DMSO solution used in biological assays. Incubation with cysteine as a model for thiol-containing biomolecules demonstrated high reactivity of the maleimide with the thiol group. In in vitro anticancer assays in human colorectal, non-small-cell lung, and cervical carcinoma cells the complexes were good to moderately active with the lowest IC50 value at 8 μm for an osmium-iodido complex.
Efficient method for the synthesis of functionalized basic maleimides
Salewska, Natalia,Milewska, Maria J.
, p. 999 - 1003 (2014/08/05)
A three-step procedure involving Diels-Alder condensation of maleic anhydride with furane, formation of N-substituted imide upon reaction with appropriate diamine, and a final retro Diels-Alder regeneration of the maleic carbon-carbon double bond is proposed for an unequivocal synthesis of N-substituted basic maleimides. The novel method is characterized by mild reaction conditions, easy work-up, high yields, and no need for additional catalysis.
MALEIMIDE COMPOUNDS AND METHODS OF TREATMENT
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Page/Page column 43; 44, (2013/03/26)
The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by formula (I): or a pharmaceutically acceptable salt thereof, wherein R, A and B are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.
Multipolar interactions in the D pocket of thrombin: Large differences between tricyclic imide and lactam inhibitors
Schweizer, Eliane,Hoffmann-Roeder, Anja,Olsen, Jacob A.,Seiler, Paul,Obst-Sander, Ulrike,Wagner, Bjoern,Kansy, Manfred,Banner, David W.,Diederich, Franois
, p. 2364 - 2375 (2008/09/18)
Two series of tricyclic inhibitors of the serine protease thrombin, imides (±)-1-(±)-8 and lactams (±)-9-(±)-13, were analysed to evaluate contributions of orthogonal multipolar interactions with the backbone CO moiety of Asn98 to the free enthalpy of pro
