4635-08-9

Basic information

• Product Name: 5-BROMO-2,3-DIAMINOPYRIDINE, 97
• Synonyms: 5-BROMO-2,3-DIAMINOPYRIDINE, 97;3-bromo-4,5-diamino-pyridin;5-Bromo-3,4-diaminepyridine;3-Bromo-4,5-pyridinediamine;5-Bromo-3,4-diaminopyridine;(3-amino-5-bromo-4-pyridyl)amine;5-BroMo-3,4-pyridinediaMine;3,4-PyridinediaMine, 5-broMo-
• CAS NO: 4635-08-9
• Molecular Formula: C₅H₆BrN₃
• Molecular Weight: 188.02524
• Product Categories: Heterocycle-Pyridine series
• Mol File: 4635-08-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 138-145℃
• Boiling Point: 370.1ºC at 760 mmHg
• Flash Point: 177.6ºC
• Appearance: White to off-white to yellow/Solid
• Density: 1.818g/cm3
• Vapor Pressure: 1.13E-05mmHg at 25°C
• Refractive Index: 1.712
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive: Moisture & Light Sensitive
• CAS DataBase Reference: 5-BROMO-2,3-DIAMINOPYRIDINE, 97(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2,3-DIAMINOPYRIDINE, 97(4635-08-9)
• EPA Substance Registry System: 5-BROMO-2,3-DIAMINOPYRIDINE, 97(4635-08-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38-43
• Safety Statements: 26-36/37/39
• RIDADR: UN2811
• RTECS: US4000000
• HazardClass: 6.1
• Hazardous Substances Data: 4635-08-9(Hazardous Substances Data)

Usage

General Description

5-Bromo-2,3-diaminopyridine, 97 refers to a chemical compound that consists of a pyridine ring substituted with a bromine atom and two amino groups. The '97' in its name suggests its purity level is 97 percent. This substance belongs to the family of pyridines and derivatives, specifically aminopyridines and derivatives. It's primarily used in the fields of chemical research and pharmaceuticals due to its unique chemical properties. It facilitates numerous chemical reactions and often acts as a building block in various compounds. Although it has wide applications, it must be handled with caution due to its potential hazards.

InChI:InChI=1/C5H6BrN3/c6-3-1-9-2-4(7)5(3)8/h1-2H,7H2,(H2,8,9)

Upstream product

• 89284-05-9 4-amino-3-bromo-5-nitropyridine 
• 1681-37-4 4-amino-3-nitropyridine 
• 26482-55-3 4-(nitroamino)pyridine 
• 504-24-5 4-aminopyridine 

Downstream Products

• 161836-12-0 7-bromo-1,3-dihydro-2H-imidazo<4,5-c>pyridin-2-one 
• 1305317-09-2 N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)benzophenone imine 
• 1305317-10-5 N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]benzophenone imine 
• 788821-74-9 8-amino-2,3-diphenylpyrido[3,4-b]pyrazine 
• 1305317-11-6 8-amino-2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazine 
• 1305317-14-9 N-(3-bromophenyl)-2,3-diphenylpyrido[3,4-b]pyrazin-8-amine 
• 1305317-15-0 N-(3-chloro-4-fluorophenyl)-2,3-diphenylpyrido[3,4-b]pyrazin-8-amine 
• 1305317-16-1 N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-ethylurea 
• 1305317-17-2 N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-phenylurea 
• 1305317-18-3 N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-(3-methoxyphenyl)urea 
• 1305317-19-4 N-(3-chlorophenyl)-N'-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)urea 
• 1305317-20-7 N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)urea 
• 1305317-22-9 N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]-N'-phenylurea 
• 1305317-24-1 N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-ethylthiourea 

Relevant articles and documents

Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and in Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model

A series of 2,4-disubstituted imidazopyridines, originating from a SoftFocus Kinase library, was identified from a high throughput phenotypic screen against the human malaria parasite Plasmodium falciparum. Hit compounds showed moderate asexual blood stage activity. During lead optimization, several issues were flagged such as cross-resistance against the multidrug-resistant K1 strain, in vitro cytotoxicity, and cardiotoxicity and were addressed through structure-Activity and structure-property relationship studies. Pharmacokinetic properties were assessed in mice for compounds showing desirable in vitro activity, a selectivity window over cytotoxicity, and microsomal metabolic stability. Frontrunner compound 37 showed good exposure in mice combined with good in vitro activity against the malaria parasite, which translated into in vivo efficacy in the P. falciparum NOD-scid IL-2Rnull (NSG) mouse model. Preliminary mechanistic studies suggest inhibition of hemozoin formation as a contributing mode of action.

Diaminopyridine compounds and methods of use

The present invention relates to compositions and method for inhibiting nonenzymatic cross-linking (protein aging) which contain diaminopyridines and derivates thereof. Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.