4640-43-1

Basic information

• Product Name: 3-Aminocyclobutanone
• Synonyms: 3-Aminocyclobutanone;Cyclobutanone, 3-amino-
• CAS NO: 4640-43-1
• Molecular Formula: C₄H₇NO
• Molecular Weight: 85.10448
• Mol File: 4640-43-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Aminocyclobutanone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Aminocyclobutanone(4640-43-1)
• EPA Substance Registry System: 3-Aminocyclobutanone(4640-43-1)

Safety Data

• Hazardous Substances Data: 4640-43-1(Hazardous Substances Data)

Usage

General Description

3-Aminocyclobutanone is a chemical compound in the category of organic cyclic compounds, specifically aminocyclobutanones. As its name suggests, its molecular structure consists of a cyclobutane ring with an amino (NH2) group and a ketone (C=O) functional group attached. Currently, this compound is not very well-studied, which means there's not much information available about its physical properties, chemical behaviour, or applications. Its potential effects, toxicity, ecological impact, or usefulness in various industries remains largely unknown and are subjects for future investigation.

Upstream product

• 130233-77-1 3-oxocyclobutane-1-carbonyl chloride 
• 23761-23-1 3-oxocyclobutanecarboxylic acid 

Downstream Products

• 154748-49-9 3-(tert-butyloxycarbonylamino)cyclobutan-1-one 
• 1449278-40-3 tert-butyl (7-(3-fluorophenyl)-4-((3-oxocyclobutyl)carbamoyl)isoquinolin-1-yl)carbamate 
• 1313759-93-1 N-(3-oxocyclobutyl)-2-naphthamide 

Relevant articles and documents

Preparation method of 3-oxocyclobutyl ammonia

The invention relates to a preparation method of 3-oxocyclobutyl ammonia. The preparation method of the 3-oxocyclobutyl ammonia comprises the following steps: conducting reaction on 3-oxocyclobutyl formamide serving as a starting material and an alkaline solution of hypohalous acid salt according to a certain proportion in a reaction solvent and 0 to 80 DEG C to prepare 3-oxocyclobutyl ammonia, diluting the system with water after the reaction, performing continuous extraction by using ethyl acetate, performing concentration under reduced pressure to obtain 3-oxocyclobutyl ammonia, and performing recrystallization on the product by diethyl ether to obtain a pure product. The preparation method of the 3-oxocyclobutyl ammonia is mild in reaction condition, high in speed, easy to operate and control and simple in aftertreatment, and the product has stable quality and high purity.

ISOXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PULMONARY DISEASES AND DISORDERS

The present disclosure features disclosed method of treating disorders such as COPD, bronchitis and/or asthma using disclosed compounds, optionally together with one or more additional active agents. Contemplated methods include administrating orally or by inhalation to a patient one or more disclosed compounds.

DERIVATIVES OF 3-HETEROARYLISOXAZOL-5-CARBOXYLIC AMIDE USEFUL FOR THE TREATMENT OF INTER ALIA CYSTIC FIBROSIS

The present disclosure is based, in part, on the discovery that disclosed compounds can increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human bronchial epithelial (hBE) cells.