4641-47-8

Usage

Uses

Used in Biochemistry:
CMPI is used as a coupling agent for the synthesis of peptides and protein conjugates, enabling the creation of complex molecular structures that are essential for understanding biological processes and developing new diagnostic tools.
Used in Drug Discovery:
In the field of drug discovery, CMPI is utilized as a catalyst in peptide coupling reactions, aiding in the development of novel therapeutic agents. Its ability to form stable amide bonds is crucial for the synthesis of bioactive peptides with potential medicinal applications.
Used in Pharmaceutical Manufacturing:
CMPI plays a significant role in pharmaceutical manufacturing, where it is employed to produce peptide-based drugs. Its use in this industry is instrumental in the large-scale production of medications that rely on peptide chemistry.
Used in the Synthesis of Polypeptide-based Biomaterials:
CMPI is used as a key component in the synthesis of polypeptide-based biomaterials, which have applications in tissue engineering, regenerative medicine, and other biomedical fields. 1-CYCLOHEXYL-3-(2-MORPHOLINOETHYL)CARBODIIMIDE METHO-P-TOLUENESULFONATE's ability to form stable peptide bonds is essential for creating functional and biocompatible materials.
Used in the Development of Peptide-based Vaccines:
In the development of peptide-based vaccines, CMPI is used as a coupling agent to link antigenic peptides to carrier proteins. This process is vital for enhancing the immunogenicity of the vaccine and stimulating a robust immune response.

Upstream product

• 111681-32-4 1-cyclohexyl-3-(2-morpholin-4-yl-ethyl)-urea 
• 2038-03-1 4-(2-AMINOETHYL)MORPHOLINE 
• 3173-53-3 Cyclohexyl isocyanate 
• 29326-79-2 (2-morpholin-4-yl-ethyl)-phosphoramidic acid diethyl ester 
• 15580-20-8 1-cyclohexyl-3-(2-morpholino-ethyl)-carbodiimide 
• 80-48-8 methyl p-toluene sulfonate 

Downstream Products

• 6778-36-5 O²,O⁵-dimethyl-L-arabinose 
• 4060-10-0 O²,O³-dimethyl-D-galactose 
• 4301-53-5 O²,O⁴-dimethyl-D-galactose 
• 4060-09-7 2.3.4-Tri-O-methyl-D-galactose 
• 15075-09-9 2.3.4.6-Tetra-O-methyl-D-mannose 
• 3615-47-2 2,3,4,6-tetra-O-methyl-D-glucose 

Relevant academic research and scientific papers

Preparation method of 1-cyclohexyl-2-(morpholinoethyl) carbodiimide methyl p-toluenesulfonate

The invention provides a preparation method of 1-cyclohexyl-2-(morpholinoethyl) carbodiimide methyl p-toluenesulfonate, and the method comprises the following steps: S1, adding N-(2-aminoethyl) morpholine into a first organic solvent, and dropwise adding cyclohexyl isocyanate to generate an intermediate 1; S2, carrying out intramolecular dehydration reaction on the intermediate 1 to obtain an intermediate 2; S3, enabling the intermediate 2 to react with methyl p-toluenesulfonate, so as to generate the 1-cyclohexyl-2-(morpholinoethyl) carbodiimide methyl p-toluenesulfonate. According to the preparation method of the 1-cyclohexyl-2-(morpholinoethyl) carbodiimide methyl p-toluenesulfonate disclosed by the embodiment of the invention, a product with high purity can be smoothly obtained, and the method is good in operability, higher and stable in yield and easily available in raw materials.

Preparation of Carbodiimides from Phosphoramidates

ω-Dialkylaminoalkylphosphoramidates are converted to ω-dialkylaminoalkyl(alkyl)carbodiimides in good yield in a two-phase system by reaction with isocyanates.

Preparation of Carbodiimides Using Phase-Transfer Catalysis

A new method is described for the preparation of carbodiimides by dehydration of ureas with arenesulfonyl chlorides under solid-liquid phase-transfer catalytic (PTC) conditions using solid potassium carbonate as a base and a lipophilic quaternary ammonium salt as a catalyst.The method is generally applicable for the synthesis of disubstituted carbodiimides, but is especially useful for unsymmetrically substituted carbodiimides.The basic carbodiimides prepared were identified in the form of the more stable, crystalline quaternary salts.