46415-29-6

Basic information

• Product Name: 1-(4-ETHOXYPHENYL)PIPERAZINE
• Synonyms: 1-(4-ETHOXYPHENYL)PIPERAZINE;4-Ethoxyphenylpiperazine;1-(4-Ethoxyphenyl)piperazine 97%;N-(4-Ethoxyphenyl) piperazine 1-(4-Ethoxyphenyl) piperazine;N-(4-Ethoxyphenyl) piperazine
• CAS NO: 46415-29-6
• Molecular Formula: C₁₂H₁₈N₂O
• Molecular Weight: 206.28
• Mol File: 46415-29-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 120 °C
• Flash Point: 169.5°C
• Appearance: /
• Density: 1.04g/cm³
• Vapor Pressure: 2.87E-05mmHg at 25°C
• Refractive Index: 1.528
• PKA: 9.02±0.10(Predicted)
• CAS DataBase Reference: 1-(4-ETHOXYPHENYL)PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-ETHOXYPHENYL)PIPERAZINE(46415-29-6)
• EPA Substance Registry System: 1-(4-ETHOXYPHENYL)PIPERAZINE(46415-29-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 46415-29-6(Hazardous Substances Data)

Usage

General Description

1-(4-Ethoxyphenyl)piperazine, also known as 4-EtO-PIP, is a psychoactive compound that belongs to the class of piperazine derivatives. It is commonly used as a research chemical and has been studied for its potential therapeutic effects on conditions such as anxiety and depression. 4-EtO-PIP has also been investigated for its potential use in the treatment of substance abuse disorders. It acts as a selective serotonin receptor agonist, meaning it interacts with the serotonin receptors in the brain, potentially affecting mood and behavior. However, its safety and efficacy for human use have not been fully established, and caution should be exercised when handling and researching this chemical.

InChI:InChI=1/C12H18N2O/c1-2-15-12-5-3-11(4-6-12)14-9-7-13-8-10-14/h3-6,13H,2,7-10H2,1H3

Upstream product

• 110-85-0 piperazine 
• 588-96-5 4-bromoethoxybenzene 
• 74-96-4 ethyl bromide 
• 158985-25-2 tert-butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate 

Downstream Products

• 83472-28-0 1-[4-(4-Ethoxy-phenyl)-piperazin-1-yl]-3-(3,7,7-trimethyl-5,9-dihydro-6,8-dioxa-2-aza-benzocyclohepten-4-yloxy)-propan-2-ol 
• 158985-01-4 3-[4-(4-ethoxyphenyl)piperazin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine 
• 1417340-56-7 2,4,7-trioxo-N'-{[4-(4-ethoxyphenyl)piperazin-1-yl]acetyl}-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidine-5-carbohydrazide 
• 1075248-04-2 C₂₂H₂₃ClN₂O₃ 

Relevant articles and documents

Potent, selective, and orally active adenosine A2A receptor antagonists: Arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines

Antagonism of the adenosine A2A receptor offers great promise in the treatment of Parkinson's disease. Employing the known pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine A2A antagonist SCH 58261 as a starting point, we identified the potent and selective (vs. A1) antagonist 11 h, orally active in the rat haloperidol-induced catalepsy model. We further optimized this lead to the methoxyethoxyethyl ether 12a (SCH 420814), which shows broad selectivity, good pharmacokinetic properties, and excellent in vivo activity.