46415-29-6

Usage

Uses

Used in Pharmaceutical Research:
1-(4-Ethoxyphenyl)piperazine is used as a research chemical for studying its potential therapeutic effects on conditions such as anxiety and depression. It is utilized to explore the interaction with serotonin receptors in the brain, which may provide insights into mood and behavior regulation.
Used in Substance Abuse Treatment Research:
4-EtO-PIP is used as a research compound in the investigation of its potential use in treating substance abuse disorders. Its interaction with serotonin receptors could offer a novel approach to managing addiction and related behaviors.
Used in Neuropharmacological Studies:
In neuropharmacological research, 1-(4-Ethoxyphenyl)piperazine serves as a selective serotonin receptor agonist, aiding in the understanding of the role of serotonin in the brain and its implications for mood disorders and other neurological conditions.

InChI:InChI=1/C12H18N2O/c1-2-15-12-5-3-11(4-6-12)14-9-7-13-8-10-14/h3-6,13H,2,7-10H2,1H3

Upstream product

• 74-96-4 ethyl bromide 
• 158985-25-2 tert-butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate 
• 110-85-0 piperazine 
• 588-96-5 4-bromoethoxybenzene 

Downstream Products

• 83472-28-0 1-[4-(4-Ethoxy-phenyl)-piperazin-1-yl]-3-(3,7,7-trimethyl-5,9-dihydro-6,8-dioxa-2-aza-benzocyclohepten-4-yloxy)-propan-2-ol 
• 158985-01-4 3-[4-(4-ethoxyphenyl)piperazin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine 
• 1417340-56-7 2,4,7-trioxo-N'-{[4-(4-ethoxyphenyl)piperazin-1-yl]acetyl}-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidine-5-carbohydrazide 
• 1075248-04-2 C₂₂H₂₃ClN₂O₃ 

Relevant academic research and scientific papers

Potent, selective, and orally active adenosine A2A receptor antagonists: Arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines

Antagonism of the adenosine A2A receptor offers great promise in the treatment of Parkinson's disease. Employing the known pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine A2A antagonist SCH 58261 as a starting point, we identified the potent and selective (vs. A1) antagonist 11 h, orally active in the rat haloperidol-induced catalepsy model. We further optimized this lead to the methoxyethoxyethyl ether 12a (SCH 420814), which shows broad selectivity, good pharmacokinetic properties, and excellent in vivo activity.

Pyrrolo-pyridine derivatives

A class of pyrrolo[2,3-b]pyridine derivatives, substituted at the 3-position by a substituted piperazinylmethyl moiety, are antagonists of dopamine receptor subtypes within the brain, having a selective affinity for the dopamine D 4 receptor subtype over other dopamine receptor subtypes, and are accordingly of benefit in the treatment and/or prevention of psychotic disorders such as schizophrenia while manifesting fewer side-effects than those associated with classical neuroleptic drugs.