464171-83-3Relevant academic research and scientific papers
An Iridium(I) N-Heterocyclic Carbene Complex Catalyzes Asymmetric Intramolecular Allylic Amination Reactions
Ye, Ke-Yin,Cheng, Qiang,Zhuo, Chun-Xiang,Dai, Li-Xin,You, Shu-Li
supporting information, p. 8113 - 8116 (2016/09/13)
A chiral iridium(I) N-heterocyclic carbene complex was reported for the first time as the catalyst in the highly enantioselective intramolecular allylic amination reaction. The current method provides facile access to biologically important enantioenriched indolopiperazinones and piperazinones in good yields (74–91 %) and excellent enantioselectivities (92–99 % ee). Preliminary mechanistic investigations reveal that the C?H activation occurs at the position ortho to the N-aryl group of the ligand.
An efficient nucleophilic carbene catalyst for the asymmetric benzoin condensation
Enders, Dieter,Kallfass, Ulrike
, p. 1743 - 1745 (2007/10/03)
The chiral bicyclic triazolium salt 1 is currently the most efficient precatalyst for the asymmetric benzoin condensation. The substituted acyloins 3 are obtained in moderate to good yields and with very good enantiomeric excesses from the corresponding aldehydes 2. The high asymmetric induction is presumably based on the conformational rigidity of the bicyclic nucleophilic carbene catalyst and on the steric hindrance of the tert-butyl group in the Breslow intermediate.
