4643-05-4

Basic information

• Product Name: (E)-3-chloroprop-2-en-1-ol
• Synonyms: (E)-3-chloroprop-2-en-1-ol;cis-3-chloroprop-2-en-1-ol
• CAS NO: 4643-05-4
• Molecular Formula: C₃H₅ClO
• Molecular Weight: 0
• Mol File: 4643-05-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 126.7°C at 760 mmHg
• Flash Point: 30.4°C
• Appearance: /
• Density: 1.148g/cm³
• Vapor Pressure: 5.29mmHg at 25°C
• Refractive Index: 1.467
• CAS DataBase Reference: (E)-3-chloroprop-2-en-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-chloroprop-2-en-1-ol(4643-05-4)
• EPA Substance Registry System: (E)-3-chloroprop-2-en-1-ol(4643-05-4)

Safety Data

• Hazardous Substances Data: 4643-05-4(Hazardous Substances Data)

Usage

General Description

(E)-3-chloroprop-2-en-1-ol, also known as 3-chloroprop-2-en-1-ol, is a chemical compound with the molecular formula C3H5ClO. It is a colorless liquid with a sharp, pungent odor, and is commonly used as a chemical intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is also used as a reagent in organic chemical reactions, and as a solvent in some industrial processes. (E)-3-chloroprop-2-en-1-ol is considered to be moderately toxic and can cause irritation to the skin, eyes, and respiratory system upon exposure. It is important to handle and use this compound with care, following proper safety protocols and guidelines.

InChI:InChI=1/C3H5ClO/c4-2-1-3-5/h1-2,5H,3H2/b2-1+

Upstream product

• 16490-99-6 ethyl (Z)-3-chloro-2-propenoate 
• 10061-01-5 cis-1,3-Dichloropropene 

Downstream Products

• 107-19-7 propargyl alcohol 
• 29560-84-7 γ-Chlorallylalkohol 
• 20604-88-0 3-chloro-propenal 

Relevant articles and documents

Fe-catalyzed synthesis of methyl-(2E,4Z)-deca-2,4-dienoate, a component of sex pheromones of Pityogenes chalcographus and Acanthoscelides obtectus

Stereoselective synthesis of methyl-(2E,4Z)-deca-2,4-dienoate, a component of sex pheromones of Pityogenes chalcographus and Acanthoscelides obtectus, was performed on the basis of Fe-catalyzed cross-coupling of methyl-(2E,4Z)-5-chloropenta-2,4-dienoate with n-pentylmagnesium bromide.

Weakly ligated palladium complexes PdCl2(RCN)2 in piperidine: Versatile catalysts for Sonogashira reaction of vinyl chlorides at room temperature

Copper iodide and weakly ligated palladium complexes PdCl2(RCN)2 (R = Ph, Me) catalyzed efficiently the coupling reaction of vinyl chlorides with 1-alkynes in the presence of piperidine to give the corresponding conjugated enynes in good to excellent yields. The reaction takes place rapidly and cleanly at room temperature. Application to the synthesis of terbinafine which exhibits strong antimycotic activity has been realized.