4643-06-5Relevant articles and documents
Preparation method of trans-3-chloro-2-propenyl hydroxylamine
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Paragraph 0041-0057, (2021/02/13)
The invention belongs to the technical field of organic synthesis, and relates to a preparation method of trans-3-chloro-2-propenyl hydroxylamine for producing clethodim technical intermediates and other pesticide important intermediates, which specifically comprises the following steps: hydrolyzing trans-1, 3-dichloropropene serving as a raw material to obtain 3-chloropropenol; and reacting the obtained 3-chloropropenol with hydroxylamine salt under the catalysis of an acidic catalyst to generate the trans-3-chloro-2-propenyl hydroxylamine. By adopting the technical scheme, the preparation method disclosed by the invention has the beneficial effects that the raw materials are easy to purchase, the operation is simple and convenient, the yield is high, no pollution is caused, and industrial production is easy.
Weakly ligated palladium complexes PdCl2(RCN)2 in piperidine: Versatile catalysts for Sonogashira reaction of vinyl chlorides at room temperature
Alami, Mouad,Crousse, Benoit,Ferri, Fabiola
, p. 114 - 123 (2007/10/03)
Copper iodide and weakly ligated palladium complexes PdCl2(RCN)2 (R = Ph, Me) catalyzed efficiently the coupling reaction of vinyl chlorides with 1-alkynes in the presence of piperidine to give the corresponding conjugated enynes in good to excellent yields. The reaction takes place rapidly and cleanly at room temperature. Application to the synthesis of terbinafine which exhibits strong antimycotic activity has been realized.