464933-37-7Relevant academic research and scientific papers
Design and synthesis of zinc-selective chelators for extracellular applications
Kawabata, Eri,Kikuchi, Kazuya,Urano, Yasuteru,Kojima, Hirotatsu,Odani, Akira,Nagano, Tetsuo
, p. 818 - 819 (2005)
Zinc (Zn2+) is found in every cell in human bodies. A few millimolar of free Zn2+ exists in the vesicles of presynaptic neurons in the mammalian brain and is released by synaptic activity or depolarization, modulating the function of certain ion channels and receptors. Although various chemical tools for measuring Zn2+ in biological samples, such as fluorescent probes for Zn2+, have been developed, Zn2+-selective chelators have room to be improved. Research on Zn2+ signals in the brain has traditionally employed several chelators, which have several shortcomings for biological applications. Here we report the design, synthesis, and properties of new membrane-impermeable chelators selective for Zn2+ and describe biological applications in hippocampal slices. As a result, our newly designed chelator revealed the first biological implication that presynaptic Zn2+ can be released in the CA1 region. This confirms the utility of these new chelatotrs as extracellular Zn2+ chelators for biological applications. Copyright
A near-infrared fluorescent sensor for detection of cyanide in aqueous solution and its application for bioimaging
Chen, Xiaoqiang,Nam, Seong-Won,Kim, Gun-Hee,Song, Nari,Jeong, Yongsuk,Shin, Injae,Kim, Seog K.,Kim, Jinheung,Park, Sungsu,Yoon, Juyoung
, p. 8953 - 8955 (2010)
A new NIR fluorescent sensor based on an amine-substituted heptamethine cyanine dye displayed a highly selective fluorescence enhancement with cyanide in aqueous solutions, and was applied for the imaging of anthropogenic and biogenic cyanide.
A fluorescent heteroditopic ligand responding to free zinc ion over six orders of magnitude concentration range
Zhang, Lu,Murphy, Christopher S.,Kuang, Gui-Chao,Hazelwood, Kristin L.,Constantino, Manuel H.,Davidson, Michael W.,Zhu, Lei
supporting information; experimental part, p. 7408 - 7410 (2010/06/17)
A fluorescent heteroditopic ligand useful in live-cell imaging studies responds to free zinc ion concentration over a range of six orders of magnitude in a buffered aqueous solution via dual-channel fluorescence.
