75860-78-5Relevant academic research and scientific papers
MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH
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Page/Page column 59, (2009/01/20)
The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.
Synthesis of thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-ones via their [1,2,4]triazolo[4,3-c]pyrimidine compounds as new ring systems by Dimroth-type rearrangement
Nagamatsu, Tomohisa,Ahmed, Shoeb,Hossion, Abugafar M.L.,Ohno, Seiji
experimental part, p. 777 - 793 (2009/09/25)
General and facile syntheses of thieno|3,2-e||1,2,4|triazolo|1,5-c|-pyrimidin-5(6H)-one (6a) and its 2-substituted derivatives (6b-j) produced by instantaneous isomerization of their |4,3-c| compounds (7a-j), which were prepared by condensation of 4-hydrazinothieno|2,3-d|pyrimidin-2(1/H)-one (10)with appropriate triethyl orthoesters or by oxidative cyclization of 4-(benzylidenehydrazino)thieno|2,3-d|pyrimidin-2(1H)-ones (11c-j), are described as novel ring systems and as a new class of potential xanthine oxidase inhibitors. The |1,5-c| isomers (6a-c) were further prepared by condensation of 3-amino-4-imino-2-oxo-1,2,3,4-tetrahydrothieno|2,3-d|pyrimidine (14) with appropriate triethyl orthoesters as a synthetic method for a reliable structure of the tricyclic ring systems.
The Synthesis of Thienopyrimidine Nucleosides related to the Naturally Occuring Nucleosides Cytidine and Uridine
Patil, Vemanna D.,Wise, Dean S.,Townsend, Leroy B.
, p. 1853 - 1858 (2007/10/02)
Several ribofuranosyl nucleosides of the thienopyrimidine ring system have been prepared by condensation of the persilylated base with 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose in 1,2-dichloroethane in the presence of stannic chloride.These nucleosides are analogues of uridine and cytidine.The synthesis of the arabinofuranosides of 4-aminothienopyrimidin-2-one and 4-amino-5-methylthienopyrimidin-2-one from a cyclonucleoside intermediate is described.
