465540-70-9

Upstream product

• 25981-83-3 5-chloro-2,3,3-trimethyl-3H-indole 
• 83-13-6 diethyl 2-phenylmalonate 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 
• 563-80-4 3-methyl-butan-2-one 

Downstream Products

• 227754-52-1 2-chloro-10,10-dimethyl-7-nitro-7-phenyl-10H-pyrido[1,2-a]indole-6,8(7H)-dione 
• 465540-77-6 2,7,9-trichloro-10,10-dimethyl-7-phenyl-10H-pyrido[1,2-a]indole-6,8(7H)-dione 

Relevant academic research and scientific papers

Synthesis and reactions of 10,10-dimethyl-10H-pyrido[1,2-a]indol-6-ones

Cyclocondensation of 2,3,3-trimethyl-3H-indoles 2 with malonates 3 gives 8-hydroxy-10,10-dimethyl-10H-pyrido[1,2-alindol-6-ones 4, which were halogenated in position 7, 8 and 9 with sulfuryl chloride, bromine or phosphoroxychloride to give the corresponding halo-10,10-dimethyl-10H-pyrido[1,2-a]indoles 5, 6, 7 and 8. Amination affords the 8-amino-10,10-dimethyl-10H-pyrido[1,2-a]indol-6-one 9. Nitration gives either the 10,10-dimethyl-7-nitro-10H-pyrido[1,2-a]indoles 10 or 10,10-dimethyl-7-hydroxy-10H-pyrido[1,2-a]indoles 11, depending on the conditions.