465613-31-4

Basic information

• Product Name: (4-Chlorophenyl)-(2-mercapto-3-methyl-3H-imidazol-4-yl)-methanol
• Synonyms: (4-Chlorophenyl)-(2-mercapto-3-methyl-3H-imidazol-4-yl)-methanol
• CAS NO: 465613-31-4
• Molecular Weight: 254.74
• Mol File: 465613-31-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (4-Chlorophenyl)-(2-mercapto-3-methyl-3H-imidazol-4-yl)-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Chlorophenyl)-(2-mercapto-3-methyl-3H-imidazol-4-yl)-methanol(465613-31-4)
• EPA Substance Registry System: (4-Chlorophenyl)-(2-mercapto-3-methyl-3H-imidazol-4-yl)-methanol(465613-31-4)

Safety Data

• Hazardous Substances Data: 465613-31-4(Hazardous Substances Data)

Upstream product

• 594-19-4 tert.-butyl lithium 
• 104-88-1 4-chlorobenzaldehyde 
• 60-56-0 2-Mercapto-1-methylimidazole 

Downstream Products

• 465615-72-9 (4-Chlorophenyl)-(3-methyl-2-propylsulfanyl-3H-imidazol-4-yl)-methanol 
• 465615-69-4 (4-chlorophenyl)-[2-(1-isopropylpiperidin-4-ylmethoxy)-3-methyl-3H-imidazol-4-yl]methanone 
• 465615-75-2 (4-Chlorophenyl)-[3-methyl-2-(propane-1-sulfonyl)-3H-imidazol-4-yl]-methanone 
• 465615-73-0 (4-Chlorophenyl)-(3-methyl-2-propylsulfanyl-3H-imidazol-4-yl)-methanone 

Relevant articles and documents

A scalable synthesis of a histamine H3 receptor antagonist

Starting from 1-methylimidazole, a concise, scalable, three-step synthesis of the title compound is described. The required 2-chloroimidazole was prepared in very good yield by halogen-metal exchange between the 2-lithio derivative and hexachloroethane.

Scalable synthesis of imidazole derivatives

Imidazole derivatives, compositions containing them, methods of preparing them, including regioselective scale-up synthetic methods, and methods of using them.