465615-75-2

Upstream product

• 465615-73-0 (4-Chlorophenyl)-(3-methyl-2-propylsulfanyl-3H-imidazol-4-yl)-methanone 
• 465615-72-9 (4-Chlorophenyl)-(3-methyl-2-propylsulfanyl-3H-imidazol-4-yl)-methanol 
• 465613-31-4 (4-Chlorophenyl)-(2-mercapto-3-methyl-3H-imidazol-4-yl)-methanol 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 465615-80-9 (4-Chlorophenyl)-[3-methyl-2-(3-piperidin-1-yl-propoxy)-3H-imidazol-4-yl]-methanone 
• 465615-69-4 (4-chlorophenyl)-[2-(1-isopropylpiperidin-4-ylmethoxy)-3-methyl-3H-imidazol-4-yl]methanone 

Relevant academic research and scientific papers

Novel imidazole-based histamine H3 antagonists

A novel series of imidazole containing histamine H3 receptor ligands were investigated and found to be potent functional antagonists. After improving the stability of these molecules towards liver microsomes, these compounds were found to have

Scalable synthesis of imidazole derivatives

Imidazole derivatives, compositions containing them, methods of preparing them, including regioselective scale-up synthetic methods, and methods of using them.

A scalable synthesis of a histamine H3 receptor antagonist

Starting from 1-methylimidazole, a concise, scalable, three-step synthesis of the title compound is described. The required 2-chloroimidazole was prepared in very good yield by halogen-metal exchange between the 2-lithio derivative and hexachloroethane.

Heterocyclic compounds

Pharmaceutically useful heterocyclic compounds, compositions containing them, and methods of using them, for example, as histamine H3 receptor mediators.