466634-84-4

Upstream product

• 14508-49-7 2-chloropyrazin 
• 619-44-3 methyl 4-iodobenzoate 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 56423-63-3 2-bromopyrazine 
• 99768-12-4 4-methoxycarbonylphenylboronic acid 
• 290-37-9 1,4-pyrazine 
• 1416276-96-4 bis[4-(methoxycarbonyl)phenyl]iodonium trifluoromethanesulfonate 

Downstream Products

• 216060-23-0 4-(pyrazin-2-yl)benzoic acid 

Relevant academic research and scientific papers

Base-Activated Latent Heteroaromatic Sulfinates as Nucleophilic Coupling Partners in Palladium-Catalyzed Cross-Coupling Reactions

Heteroaromatic sulfinates are effective nucleophilic reagents in Pd0-catalyzed cross-coupling reactions with aryl halides. However, metal sulfinate salts can be challenging to purify, solubilize in reaction media, and are not tolerant to multi-step transformations. Here we introduce base-activated, latent sulfinate reagents: β-nitrile and β-ester sulfones. We show that under the cross-coupling conditions, these species generate the sulfinate salt in situ, which then undergo efficient palladium-catalyzed desulfinative cross-coupling with (hetero)aryl bromides to deliver a broad range of biaryls. These latent sulfinate reagents have proven to be stable through multi-step substrate elaboration, and amenable to scale-up.

KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE

Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.

Room-temperature arylation of arenes and heteroarenes with diaryliodonium salts by photoredox catalysis

Aryl radicals produced by irradiation of diaryliodonium salts with visible light under the catalysis of [Ru(bpy)3]2+ undergo coupling with a wide range of arenes and heteroarenes, affording various biaryls through direct C-H arylation at room temperature. Georg Thieme Verlag Stuttgart · New York.

Syntheses of substituted pyridines, quinolines and diazines via palladium-catalyzed cross-coupling of aryl Grignard reagents

The palladium-catalyzed cross-coupling reactions between arylmagnesium halides (phenylmagnesium chloride, mesitylmagnesium bromide, 4-(methoxycarbonyl)phenylmagnesium chloride and 4-cyanophenylmagnesium chloride) and halopyridines allowed the synthesis of substituted pyridines. Owing to the remarkably mild conditions used (often below 0°C), the reaction could be extended to the use of functionalized halopyridines, haloquinolines and halodiazines.