56423-63-3Relevant articles and documents
Synthesis and Characterization of 2-(2-Pyridinyl)pyrazine and 2,2′-Bipyrazine Derivatives
KomReddy, Venugopal,Rillema, D. Paul,Nguyen, Huy,Kadel, Lava
, p. 972 - 979 (2019/02/05)
A convenient and high yield preparation of derivatives of 2-(2-pyridinyl)pyrazine and derivatives of 2,2′-bipyrazine compounds from their derivatives of bromopyrazine using Stille coupling is reported. X-ray structures, elemental analyses, 1H, 13C-NMR, and mass spectral data of the compounds are given.
Metalation of bromodiazines. Diazines XL
Decrane, Laurence,Pie, Nelly,Turck, Alain
, p. 509 - 513 (2007/10/03)
The syntheses of 2-bromopyrazine, 2,4-dibromopyrimidines, and 3-bromo-6-phenylpyrazine were improved and their metalation with lithium alkylamides was studied.
Silyl-mediated halogen/halogen displacement in pyridines and other heterocycles
Schlosser, Manfred,Cottet, Fabrice
, p. 4181 - 4184 (2007/10/03)
Heating with bromotrimethylsilane converts 2-chloropyridine into 2-bromopyridine and 2-chloro-6-methylpyridine into 2-bromo-6-methylpyridine. Both 2-chloropyridines and 2-bromopyridines give the corresponding iodo compound when treated with in situ generated iodotrimethylsilane. Although 3- and 4-chloropyridine are completely inert, 2,4-dichloropyridine undergoes the halogen/halogen exchange simultaneously at the 2- and 4-position. Halogen displacement takes place exclusively at the 2-position with 2,3-dichloropyridine and 2,5-dichloropyridine. In agreement with the intermediacy of N-trimethylsilylpyridinium salts as a prerequisite for the occurrence of halogen exchange, neither 2-fluoropyridine and 2-fluoro-6-methylpyridine nor any 2,6-dihalopyridine reacts. Finally, bromine/chlorine and iodine/chlorine substitution can also be accomplished with 2-or 4-chloroquinoline, 1-chloroisoquinoline, 2-chloropyrimidine, chloropyrazine and 2,3-dichloroquinoxaline as substrates. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2002).