466651-75-2

Upstream product

• 466651-68-3 (4R,2S)-4-(tert-butyldimethylsilanyloxy)-2-[((R)-4-ethoxycarbonyl)thiazolidin-2-yl]-1-(p-nitrobenzyloxycarbonyl)pyrrolidine 
• 137049-21-9 (2S,4R)-2-formyl-4-tert-butyldimethylsilyloxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 124-63-0 methanesulfonyl chloride 
• 466651-74-1 (4R,2S)-4-(tert-butyldimethylsilanyloxy)-2-[((R)-4-carbamoyl)thiazolidin-2-yl]-1-(p-nitrobenzyloxycarbonyl)pyrrolidine 

Downstream Products

• 466651-91-2 (2S,4S)-2-((R)-4-Carbamoyl-thiazolidin-2-yl)-4-mercapto-pyrrolidine-1-carboxylic acid 4-nitro-benzyl ester 
• 466652-05-1 (4R,5S,6S)-3-[(3S,5S)-5-((R)-4-Carbamoyl-thiazolidin-2-yl)-1-(4-nitro-benzyloxycarbonyl)-pyrrolidin-3-ylsulfanyl]-6-((R)-1-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 

Relevant academic research and scientific papers

Synthesis and antibacterial activity of 1β-methyl-2-(5-substituted thiazolidinopyrrolidin-3-ylthio)carbapenems and related compounds

The synthesis of a new series of 1β-methylcarbapenems containing the substituted thiazolidinopyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituent on the thiazolidine ring was investigated. A particular compound (18c) having a 2-amide substituted thiazolidine moiety showed the most potent antibacterial activity.