4671-96-9

Usage

Chemical class

Aldehydes
1-Piperidineacetaldehyde is an organic compound that belongs to the aldehyde class.

Physical state

Colorless liquid
The compound appears as a colorless liquid.

Odor

Pungent
1-Piperidineacetaldehyde has a pungent odor.

Applications

Synthesis of pharmaceuticals and agrochemicals
1-Piperidineacetaldehyde is commonly used in the synthesis of various pharmaceuticals and agrochemicals.

Flavor and fragrance ingredient

Production of perfumes and scented products
The compound is used as a flavor and fragrance ingredient in the production of perfumes and other scented products.

Antimicrobial properties

Useful in antimicrobial agents development
1-Piperidineacetaldehyde has been found to have antimicrobial properties, making it useful in the development of antimicrobial agents.

Antifungal properties

Useful in antifungal agents development
The compound also has antifungal properties, which can be useful in the development of antifungal agents.

Organic chemistry applications

Building block for complex molecule synthesis
1-Piperidineacetaldehyde has potential applications in the field of organic chemistry and can serve as a building block for the synthesis of other complex molecules.

Upstream product

• 3616-58-8 1-piperidinyl-acetaldehyde diethyl acetal 
• 110-89-4 piperidine 
• 22633-62-1 1-(2,2-dimethoxyethyl)piperidine 

Downstream Products

• 102588-30-7 2-Piperidinoethanal-oxim 
• 101048-77-5 2-chloro-4-formylbenzonitrile 
• 17590-23-7 3-(1-methyl-2-phenyl-ethyl)-4-piperidin-1-ylmethyl-sydnone 
• 17590-20-4 3-(1-methyl-2-phenyl-ethyl)-5-nitrosoamino-4-piperidin-1-ylmethyl-[1,2,3]oxadiazolium betaine 

Relevant academic research and scientific papers

Design, synthesis, antiproliferative activity and docking studies of quinazoline derivatives bearing 2,3-dihydro-indole or 1,2,3,4-tetrahydroquinoline as potential EGFR inhibitors

Eight series of quinazoline derivatives bearing 2,3-dihydro-indole or 1,2,3,4-tetrahydroquinoline were designed, synthesized and evaluated for the IC50 values against three cancer cell lines (A549, MCF-7 and PC-3). Most of the forty nine target compounds showed excellent antiproliferative activity against one or several cancer cell lines. The compound 13a showed the best activity against A549, MCF-7 and PC-3 cancer cell lines, with the IC50 values of 1.09 ± 0.04 μM, 1.34 ± 0.13 μM and 1.23 ± 0.09 μM, respectively. Eight selected compounds were further selected to evaluated for the inhibitory activity against EGFR kinase. Three of them showed equal activity against EGFR kinase to positive control afatinib. AnnexinV-FITC, propidium iodide (PI) double staining and acridine orange single staining results indicated that the compound 13a could induce apoptosis of human lung cancer A549 cells.

Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: Key precursors to potent c-Met inhibitors

An effective one-pot synthesis of quinolines bearing diverse C3-piperazinyl functions was developed by using a modified Friedlaender's protocol. The method not only enables the synthesis of our early reported c-Met inhibitor on a large scale, but also provides a way to generate novel multi-substituted quinolines for further structure-activity relationship (SAR) study.