467223-91-2

Basic information

• Product Name: 1-fluoro-3-(2-iodoethyl)benzene
• Synonyms: 1-fluoro-3-(2-iodoethyl)benzene
• CAS NO: 467223-91-2
• Molecular Weight: 250.054
• Mol File: 467223-91-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-fluoro-3-(2-iodoethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-fluoro-3-(2-iodoethyl)benzene(467223-91-2)
• EPA Substance Registry System: 1-fluoro-3-(2-iodoethyl)benzene(467223-91-2)

Safety Data

• Hazardous Substances Data: 467223-91-2(Hazardous Substances Data)

Usage

Description

Colorless liquid

Molecular weight

257.05 g/mol

Usage

Intermediate in the synthesis of pharmaceuticals and agrochemicals

Usage

Building block for the creation of various organic compounds

Functional groups

Fluorine group and iodine group attached to a benzene ring

Reactivity

Useful for a variety of chemical reactions

Importance

Wide range of applications in organic chemistry

Upstream product

• 26416-23-9 2-(3-fluorophenyl)ethyl 4-methylbenzenesulfonate 
• 64123-77-9 methyl (3-fluorophenyl)acetate 
• 331-25-9 (3-fluorophenyl)acetic acid 
• 52059-53-7 2-(3-fluorophenyl)ethanol 

Downstream Products

• 467223-85-4 (+)-octahydro-3,6α-dimethyl-3,12-epoxy-9α-(3'-(m-fluorophenyl)propyl)-12H-pyrano[4,3j]-1,2-benzodioxepin-10(3H)-one 
• 467224-04-0 (+)-octahydro-3,6α-dimethyl-3,12-epoxy-9β-(3'-(m-fluorophenyl)propyl)-12H-pyrano[4,3j]-1,2-benzodioxepin-10(3H)-one 
• 1208110-12-6 (2S)-1'-[2-(3-fluorophenyl)ethyl]-6-methoxy-3,4-dihydro-1Hspiro[naphthalene-2,2'-piperidin]-1-one 
• 1208110-14-8 (2S)-1'-[2-(3-fluorophenyl)ethyl]-6-methoxy-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one hydrochloride 
• 467223-96-7 C₂₃H₃₁FO₅ 

Relevant articles and documents

Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1H-spiro(naphthalene-2,2′-piperidin)-1-ones as potassium-competitive acid blockers

With the aim to discover a gastric antisecretory agent more potent than the existing proton pump inhibitors, novel 3,4-dihydro-1H-spiro(naphthalene-2,2′-piperidin)-1-one derivatives, which could occupy two important lipophilic pockets (described as LP-1 and LP-2) of H+,K+-ATPase and can strongly bind to the K+-binding site, were designed based on a docking model. Among the compounds synthesized, compound 4d showed a strong H+,K+-ATPase-inhibitory activity and a high stomach concentration in rats, resulting in potent inhibitory action on histamine-stimulated gastric acid secretion in rats. Furthermore, 4d exerted significant inhibitory action on histamine-stimulated gastric-acid secretion in rats with a rapid onset and moderate duration of action after the administration. These findings may lead to a new insight into the drug design of potassium-competitive acid blockers.

ARTEMISININ-BASED PEROXIDE COMPOUNDS AS BROAD SPECTRUM ANTI-INFECTIVE AGENTS

Described herein is the synthesis, bioassay results and utility of new C-9 and C-10 substituted artemisinin derivatives with easily functionalizable groups attached to the artemisinin skeleton through carbon chain or heteroatoms. Described also is the demonstration of this class of compounds for their broad-spectrum anti-parasitic activity. Certain of these analogs possess noticeable cytotoxicity deliberately focused on treatment of cancerous diseases.