467427-49-2

Upstream product

• 467427-42-5 4-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-3-chloro-benzaldehyde 
• 467427-41-4 4-benzyloxy-3-chloro-2-hydroxy-benzaldehyde 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 131088-00-1 3-chloro-2,4-dihydroxylbenzaldehyde 
• 100-39-0 benzyl bromide 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 13154-24-0 triisopropylsilyl chloride 

Downstream Products

• 467427-38-9 2-[2-{2-tert-butoxycarbonylamino-2-[3,5-dibromo-4-(pyrrolidin-1-ylazo)-phenyl]-acetylamino}-2-(4-methoxy-phenyl)-acetylamino]-3-[2-(tert-butyl-dimethyl-silanyloxy)-3-chloro-4-hydroxy-phenyl]-3-triisopropylsilanyloxy-propionic acid ethyl ester 
• 467427-51-6 (2S,3S)-2-[(R)-2-Amino-2-(4-methoxy-phenyl)-acetylamino]-3-[2-(tert-butyl-dimethyl-silanyloxy)-3-chloro-4-hydroxy-phenyl]-3-triisopropylsilanyloxy-propionic acid ethyl ester 
• 467427-50-5 2-[2-tert-butoxycarbonylamino-2-(4-methoxy-phenyl)-acetylamino]-3-[2-(tert-butyl-dimethyl-silanyloxy)-3-chloro-4-hydroxy-phenyl]-3-triisopropylsilanyloxy-propionic acid ethyl ester 

Relevant academic research and scientific papers

Atropselective macrocyclization of diaryl ether ring systems: Application to the synthesis of vancomycin model systems

Vancomycin is the last line of defense available in the clinic for treating multidrug-resistant bacterial infections. Vancomycin contains two 16-membered diaryl ether macrocycles, each of which contains a stereogenic axis across the diaryl ether linkage.