467429-19-2Relevant academic research and scientific papers
Copper-carbene complexes as catalysts in the synthesis of functionalized styrenes and aliphatic alkenes
Lebel, Helene,Davi, Michael,Diez-Gonzalez, Silvia,Nolan, Steven P.
, p. 144 - 149 (2007/10/03)
(NHC)-Cu (NHC = N-heterocyclic carbene) complexes efficiently catalyzed the methylenation of a variety of aliphatic and aromatic aldehydes and ketones in the presence of trimethylsilyldiazomethane, triphenylphosphine, and 2-propanol. The copper catalysts are not only inexpensive compared to rhodium complexes, but they also exhibit better functional group compatibility with aromatic aldehydes and ketones. Indeed very high yields were obtained for the formation of styrenes containing nitro, trifluoromethyl, amino, and ester groups, as well as for pyridine-, pyrrole-, and indole-substituted alkenes.
Multicatalytic processes using diverse transition metals for the synthesis of alkenes
Lebel, Helene,Paquet, Valrie
, p. 11152 - 11153 (2007/10/03)
A series of cascade processes for the synthesis of alkenes from alcohols is described. Each individual step is catalyzed with a specific transition metal complex. The oxidation-methylenation one-pot procedure took place in the presence of a palladium and a rhodium catalyst to produce the desired terminal alkenes in high yields. A methylenation-ring-closing metathesis allowed the synthesis of cyclic alkenes from carbonyl derivatives, using the second-generation metathesis catalyst. Finally, an oxidation-methylenation-RCM process that involves up to three different transition metal catalysts in the same vessel is presented. Copyright
Alternative routes to pterulone
Kahnberg, Pia,Lee, Choon Woo,Grubbs, Robert H,Sterner, Olov
, p. 5203 - 5208 (2007/10/03)
Two new synthetic routes to pterulone, a fungal metabolite possessing potent antifungal activity as an inhibitor of NADH/ubiquinone oxidoreductase, are reported.
