68840-08-4

Usage

InChI:InChI=1/C9H8O3/c1-6(11)7-2-3-9(12)8(4-7)5-10/h2-5,12H,1H3

Upstream product

• 531-99-7 5-acetyl-2-methoxybenzaldehyde 
• 50-00-0 formaldehyd 
• 99-93-4 4-Hydroxyacetophenone 
• 108-24-7 acetic anhydride 
• 90-02-8 salicylaldehyde 
• 5663-67-2 2-acetoxybenzaldehyde 
• 74-89-5 methylamine 
• 89-95-2 2-methyl-benzyl alcohol 

Downstream Products

• 467429-18-1 5-acetyl-2-[(but-3-enyl)oxy]-benzaldehyde 
• 467429-19-2 1-{4-[(but-3-enyl)oxy]-3-vinylphenyl}-ethanone 
• 467429-20-5 2-{4-[(but-3-enyl)oxy]-3-vinylphenyl}-2-methyl-[1,3]dioxolane 
• 1000781-23-6 C₁₂H₁₄O₃ 
• 115787-50-3 5-(2-bromoacetyl)-2-hydroxybenzaldehyde 
• 1448818-06-1 C₁₀H₈Br₂O₂ 

Relevant academic research and scientific papers

Synthesis method of 5-(2-bromoacetyl)-2-hydroxybenzaldehyde

The invention discloses a synthesis method of 5-(2-bromoacetyl)-2-hydroxybenzaldehyde, and belongs to the field of medicine synthesis. According to the method, the acylation reaction is conducted withsalicylaldehyde as the raw material to obtain 2-(acetoxyl)-benzaldehyde, then the rearrangement reaction is conducted, and finally the bromination reaction is conducted to obtain 5-(2-bromoacetyl)-2-hydroxybenzaldehyde. The preparing method has the advantages of being high in product purity and high in yield.

Highly efficient synthesis of chalcones from poly carbonyl aromatic compounds using bf3-et2o via a regioselective condensation reaction

A new, simple, highly efficient method for the synthesis of different types of carbonyl chalcones through a regioselective condensation reaction of appropriate 5-acetyl-2-hydroxybenzaldehyde with various substituted acetophenones and 4-hydroxyisothalaldehyde with various substituted aldehydes using BF3-Et2O as a reagent is described.

Preparation method of substituted benzobfuran-2-formamide

The invention belongs to the technical field of medicine, and discloses a preparation method of substituted benzobfuran-2-formamide (please see the formula in the specification). A compound shown in the formula (2) is obtained by removing the protecting group of a compound (3), and then 5-(1-piperazinyl)-benzofuran-2-formamide (1) is obtained through ammonolysis. The method overcomes the defects of an existing preparation method, operation is easy, use of expensive catalysts is avoided, intermediates can be conveniently separated, and cost is low.

Synthesis of chromanones: A novel palladium-catalyzed Wacker-type oxidative cyclization involving 1,5-hydride alkyl to palladium migration

A series of 2-methylchromanone derivatives have been prepared by using a novel palladium-catalyzed Wacker-type oxidative cyclization, in which a 1,5-hydride alkyl to palladium migration and a direct chirality transfer were involved. The Royal Society of Chemistry.

Fungicidal 1-benzoxepin derivatives

The invention concerns novel 1-benzoxepin derivatives, methods for preparing them, their use as fungicides, in particular in the form of fungicidal compositions, as well as methods for controlling phytopathogenic fungi of crops using said compounds or said compositions.

Alternative routes to pterulone

Two new synthetic routes to pterulone, a fungal metabolite possessing potent antifungal activity as an inhibitor of NADH/ubiquinone oxidoreductase, are reported.

Convenient Method for the ortho-Formylation of Phenols

Phenolic derivatives are formylated selectively ortho to the hydroxy group by paraformaldehyde with magnesium dichloride-triethylamine as base. With alkyl-substituted phenols excellent yields of the corresponding salicylaldehyde derivatives were obtained. Similar results were obtained with chloro-substituted phenols and with 3- and 4-methoxyphenol, while 2-methoxyphenol was unreactive. A good yield of methyl 3-formyl-4-hydroxybenzoate was obtained by this method as well, but generally phenols with electron-attracting groups reacted sluggishly; the long reaction times required caused the formation of by-products, particularly MOM-derivatives of the phenols.

An Improved Synthesis of 2-Nitrobenzofurans

2-Nitrobenzofurans 4 are prepared in improved yields by reacting o-hydroxybenzaldehydes 1 and bromonitromethane (2) at low temperature in order to avoid the dehydration of the aldol intermediate 3 in the alkaline condensation medium.This aldol 3 is then quantitatively dehydrated by heating in acetic anhydride.