46744-29-0Relevant academic research and scientific papers
Method for producing N-alkylpiperazine
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Paragraph 0058; 0063, (2017/02/09)
PROBLEM TO BE SOLVED: To provide a method for producing N-alkyl piperazines in high yield by selectively alkylating one amino group.SOLUTION: In the method for producing N-alkyl piperazines, piperazines represented by general formula (1) are reacted with a specific alkylating agent in the presence of an acid. In the formula: R-Rare each independently a hydrogen atom, a methyl group, an ethyl group, a 3-8C linear alkyl group or the like, a hydroxyethyl group, a hydroxypropyl group, a dihydroxypropyl group, a methoxy group, an ethoxy group, a phenyl group, a benzyl group, a 2-phenylethyl group, or the like.
SYNTHESIS OF MONO- AND BIS(HYDROXYALKYL)PIPERAZINES.
Mislyuk,Shibaev,Davidenkov,V'yunov,Ginak
, p. 1982 - 1983 (2007/10/02)
The known methods for production of mono- and bis(hydroxyalkyl)piperazines are based on the reaction of ethylene oxide with unsubstituted piperazine, but the connection between alkylation of piperazine and the side reaction of oligomerization of alpha -oxides under the influence of catalytic amounts of piperazine has still not been clarified. The interaction of piperazine with substituted alpha -oxides has not been studied at all. We showed with reference to the reactions of piperazine with substituted alpha -oxides that opening of the oxirane ring proceeds exclusively with formation of mono- (I-IV) and N,N prime -bis(hydroxyalkyl)piperazines (V-VIII) in yields of 85-95% calculated on the alpha -oxide. The authors show that the two molecules of the asymmetric alpha -oxide add on exclusively at the nitrogen atoms of the heterocycle, and that oligomerization of the alpha -oxide and addition of its second molecule at the hydroxyl groups of mono(hydroxyalkyl)piperazines (I-IV) make no appreciable contribution. The presence of free hydroxyl groups in compounds (I-VIII) offers possibilities of chemical bonding in epoxy compositions.
