467442-27-9

Upstream product

• 74124-79-1 di(succinimido) carbonate 
• 6908-41-4 4-(methoxycarbonyl)benzyl alcohol 

Downstream Products

• 1429926-21-5 C₂₁H₂₆N₂O₄ 
• 1429926-22-6 C₃₉H₄₉N₃O₈ 
• 1429926-23-7 C₃₈H₄₇N₃O₈ 
• 1429926-30-6 C₃₄H₄₁N₃O₇ 
• 99-75-2 4-methyl-benzoic acid methyl ester 
• 1429926-20-4 C₂₆H₃₄N₂O₆ 

Relevant academic research and scientific papers

Glycosylation efficiencies on different solid supports using a hydrogenolysis-labile linker

Automated oligosaccharide assembly requires suitable linkers to connect the first monosaccharide to a solid support. A new hydrogenolysis-labile linker that is stable under both acidic and basic conditions was designed, synthesized and coupled to different resins. Glycosylation and cleavage efficiencies on these functionalized solid supports were investigated, and restrictions for the choice of solid support for oligosaccharide synthesis were found.

PYRROLIDINE DERIVATIVE OR SALT THEREOF

[PROBLEMS] To provide a compound which can be used for the treatment of a disease associated with a calcium-sensing receptor (CaSR), particularly hyperparathyroidism. [MEANS FOR SOLVING PROBLEMS] It is found that a novel pyrrolidine derivative having an aminomethyl group substituted by an arylaklyl group or the like or a salt thereof has an excellent CaSR agonistic modulation effect and also has an excellent selectivity in the inhibition of CYP2D6 which may cause a drug-drug interaction. Thus, the novel pyrrolidine derivative is useful as a therapeutic agent for a disease associated with CaSR (e.g., hyperparathyroidism, renal osteodystrophy and hypercalcemia).