467443-76-1

Upstream product

• 42486-87-3 3,5-dinitro-4-chlorobenzenecarboxylic acid chloride 
• 118-97-8 4-chloro-3,5-dinitrobenzoic acid 
• 130145-33-4 4-chloro-3,5-dinitro-benzoyl azide 

Downstream Products

• 130145-34-5 methyl (4-chloro-3,5-dinitrophenyl)carbamate 
• 467443-34-1 2-[3-(4-chloro-3,5-dinitro-phenyl)-2,4,5-trioxo-imidazolidin-1-yl]-propionic acid ethyl ester 
• 130145-36-7 methyl <4-<(2,2-diethoxy-1-phenylethyl)amino>-3,5-dinitrophenyl>carbamate 
• 130145-37-8 methyl <4-<<α-methoxycarbonyl)benzyl>amino>-3,5-dinitrophenyl>carbamate 
• 130145-48-1 methyl (5-amino-1,2,3,4-tetrahydro-2-oxo-3-phenylbenzopyrazin-7-yl)carbamate 
• 130145-49-2 (8-Amino-2-phenyl-1,2,3,4-tetrahydro-quinoxalin-6-yl)-carbamic acid methyl ester 
• 130145-43-6 methyl (5-amino-1,2-dihydro-2-oxo-3-phenylbenzopyrazin-7-yl)carbamate 
• 130145-41-4 methyl (5-amino-1,2-dihydro-3-phenylbenzopyrazin-7-yl)carbamate 
• 130145-45-8 4-amino-3,5-dinitro-1-(methoxycarbonylamino)benzene 
• 130145-42-5 methyl (5-amino-3-phenylbenzopyrazin-7-yl)carbamate 
• 130145-46-9 methyl (3,4,5-triaminophenyl)carbamate 

Relevant academic research and scientific papers

Synthesis, selective aldose reductase inhibitory profile and antihyperglycaemic potential of certain parabanic acid derivatives

Synthesis and aldose reductase inhibitory profile of certain parabanic acid derivatives 1a-p is described. Also, the antihyperglycaemic potential of these compounds was studied. The most active inhibitors in this series were compounds 1 g, 1p, and 1o which showed inhibitory activity, 36.6, 90 and 91% respectively, at concentration 1 × 10-4. Their IC50 were 2 × 10-6, 7.5 × 10-8 and 5 × 10-8, respectively. Compound 1o exhibited pronounced antihyperglycaemic effect.

Potential Antimitotic Agents. Synthesis of Some Ethyl Benzopyrazin-7-ylcarbamates, Ethyl Pyridopyrazin-7-ylcarbamates, and Ethyl Pyrido-as-triazin-7-ylcarbamates

Ring analogues and derivatives of the 1,2-dihydropyridopyrazin-7-ylcarbamates (e.g., 29), antimitotic agents with antitumor activity, were prepared in the search for compounds with greater selectivity.Methods were developed for the conversion of su