46745-60-2Relevant academic research and scientific papers
N1,N1-dimethyl-N3-(3-(trifluoromethyl) phenethyl)propane-1,3-diamine, a new lead for the treatment of human African trypanosomiasis
Pham, Ngoc B.,Deydier, Sophie,Labaied, Mehdi,Monnerat, Severine,Stuart, Kenneth,Quinn, Ronald J.
, p. 541 - 551 (2014/03/21)
The natural product, convolutamine I (1), has anti-trypanosomal activity however it has a high molecular weight of 473 due to a presence of 3 bromine atoms. The synthesis of the natural product convolutamine I (1) together with its analogues are presented. A SAR study against Trypanosoma brucei brucei led to compounds with improved physico-chemical properties: lower molecular weight and lower log P while maintaining potency (with a slight 2-fold improvement).
