46779-48-0

Usage

Uses

Used in Pharmaceutical Industry:
1-Methyl-4-tosylpiperazine is used as a key intermediate for the synthesis of various drugs, contributing to the development of new pharmaceuticals with specific therapeutic effects. Its functional groups facilitate the creation of molecules with targeted biological activities, making it an essential component in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 1-Methyl-4-tosylpiperazine is utilized as a precursor in the production of pesticides. Its chemical properties allow for the development of effective compounds that can protect crops and control pests, thereby enhancing agricultural productivity.
Used in Organic Synthesis:
1-Methyl-4-tosylpiperazine is used as a building block in the synthesis of other organic compounds, showcasing its versatility in creating a diverse range of molecules. Its presence in various chemical reactions highlights its importance in the field of organic chemistry.
Used in Research and Development:
1-Methyl-4-tosylpiperazine is also employed in research and development for the creation of new molecules with specific biological activities. Its potential applications in medicinal chemistry for the development of innovative drugs and therapeutics make it a valuable asset in scientific exploration and advancement.

InChI:InChI=1/C12H18N2O2S/c1-11-3-5-12(6-4-11)17(15,16)14-9-7-13(2)8-10-14/h3-6H,7-10H2,1-2H3

Upstream product

• 109-01-3 1-methyl-piperazine 
• 941-55-9 4-toluenesulfonyl azide 
• 98-59-9 p-toluenesulfonyl chloride 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 16695-22-0 N,N-bis(tosyloxyethyl)-p-toluenesulfonamide 
• 110-70-3 N,N`-dimethylethylenediamine 

Relevant academic research and scientific papers

Three-component synthesis of N-sulfonylformamidines in the presence of magnetic cellulose supported N-heterocyclic carbene-copper complex, as an efficient heterogeneous nanocatalyst

A cellulose based magnetic nanocomposite possessing NHC-Cu Complex has been synthesized and characterized. It was then applied as a highly active catalyst in one-pot three-component reaction of sulfonyl azides, secondary amines and triethylamine to afford

NH4I-Catalyzed Synthesis of Sulfonamides from Arylsufonylhydrazides and Amines

A novel and efficient approach to sulfonamides has been developed. Using TBHP as the oxidant and NH4I (20 mol%) as the catalyst, arylsulfonyl hydrazides reacted with amines to provide sulfonamides in moderate to good yields. Possible reaction pathway for the formation of the products was also discussed in this paper. Sulfonimides were synthesized through the oxidation coupling of arylsufonylhydrazides and amines by TBHP/NH4I system in moderate to good yields.

Iodine-catalyzed expeditious synthesis of sulfonamides from sulfonyl hydrazides and amines

A new synthesis of sulfonamides has been developed via an iodine-catalyzed sulfonylation of amines with arylsulfonyl hydrazides. This metal-free strategy employs readily accessible and easy to handle starting materials, catalysts and oxidants, and can be easily conducted under mild conditions, providing a convenient access to a wide range of sulfonamides in moderate to excellent yields within a short reaction time.

Iodine-catalyzed oxidative amination of sodium sulfinates: A convenient approach to the synthesis of sulfonamides under mild conditions

The iodine-catalyzed oxidative amination of sodium sulfinates in the presence of sodium percarbonate as the oxidant has been developed. The reaction shows good substrate scope and tolerates a wide range of functionalities in both amine and sodium sulfinate substrates. Aliphatic amines, heteroaromatic amines and hydrochloride salts of amines canbe employed as the amine sources in this transformation. Mechanistic studies indicated that a radical pathway might be involved in the reaction process. This transition-metalfree protocol offers an alternative and convenient approach for a preparation of a series of sulfonamides in moderate to good yields under mild conditions.

DABCO-bis (sulfur dioxide), DABSO, as a convenient source of sulfur dioxide for organic synthesis: Utility in sulfonamide and sulfamide preparation

The charge-transfer complex generated from the combination of DABCO and sulfur dioxide, DABSO, is a bench-stable colorless solid suitable for use in organic synthesis as a replacement for gaseous sulfur dioxide. The complex can be combined with Grignard reagents to form sulfinates, which can then be converted in situ to a series of sulfonamides. Alternatively, reaction with anilines and iodine leads to the formation of a series of sulfamides. Cheletropic addition between DABSO and 2,3-dimethylbutadiene provides the corresponding sulfolene.

An improved synthesis of 1,4,7-triazacyclononanes (tacns) and 1,4,7,10-tetraazacyclododecanes (cyclens)

Reaction of tosylbis[2-(tosyloxy)ethyl]amine with ethylenediamine gives 1-tosyl-1,4,7-triazacyclononane in good yield. A similar reaction of tosylbis[2-(tosyloxy)ethyl]amine with diethylenetriamine gives 1-tosyl-1,4,7,10-tetraazacyclododecane. These tosyl

Design, synthesis and antimalarial activity of benzene and isoquinoline sulfonamide derivatives

A new series of benzene and isoquinoline sulfonamide derivatives were synthesized by nucleophilic displacement reaction on benzene and isoquinoline sulfonyl chlorides by substituted amines (primary and secondary). The title compounds were evaluated for an

Benzene sulfonamides as PDE-V inhibitors for the use against erectile dysfunction

The compounds of formula (I) wherein X, R0, R1, R2, n and m have the meanings given in the specification, are useful as active ingredients in pharmaceutical compositions. The invention relates to the use of said compounds as a medicament and for the manufacture of a medicament for the treatment of erectile dysfunction.