4679-83-8

Upstream product

• 34219-51-7 (E)-1-methyl-3-benzylidene-2,3-dihydro-1H-indol-2-one 
• 71-43-2 benzene 
• 62-53-3 aniline 
• 7342-02-1 3-phenylpropynoic acid phenylamide 
• 61-70-1 N-methyl-2-indolinone 
• 91-01-0 1,1-Diphenylmethanol 
• 591-50-4 iodobenzene 
• 98-80-6 phenylboronic acid 
• 267408-61-7 N-(2'-Bromophenyl)-N-methylpropynamide 
• 201230-82-2 carbon monoxide 
• 1608465-82-2 C₂₁H₁₉N 
• 267408-59-3 N-(2'-Bromophenyl)propynamide 
• 898138-80-2 N-(2-bromophenyl)-3-phenylpropiolamide 
• 637-44-5 phenylpropyolic acid 

Downstream Products

• 4679-78-1 1-methyl-3',3'-diphenyl-1H-spiro[indole-3,2'-oxiran]-2-one 

Relevant academic research and scientific papers

Palladium Nanoparticle-Catalyzed Stereoselective Domino Synthesis of All-Carbon Tetrasubstituted Olefin Containing Oxindoles via Carbopalladation/C-H Activation

The binaphthyl stabilized palladium nanoparticles (Pd-BNP) catalyzed single-step, stereoselective domino synthesis of symmetrically and unsymmetrically all-carbon tetrasubstituted olefin containing oxindoles from readily accessible anilides has been devel

Ru-Catalyzed dehydrogenative synthesis of antimalarial arylidene oxindoles

Ru(ii)-NHC catalyzes α-olefination of 2-oxindoles using diaryl methanols in the absence of an acceptor. A wide array of symmetrical and unsymmetrical diaryl methanols undergoes dehydrogenative coupling with 2-oxindole selectively to generate various substituted 3-(diphenylmethylene)indolin-2-one derivatives in good yields and produces environmentally benign by-products, H2 and H2O. This methodology was successfully applied for the synthesis of a bioactive drug i.e. TAS-301. The biological activities of the synthesized 3-(diphenylmethylene)indolin-2-one derivatives were screened against the Plasmodium falciparum parasite and found to exhibit a significant activity with IC50 = 2.24 μM.

Consecutive one-pot versus domino multicomponent approaches to 3-(Diarylmethylene)oxindoles

Based on consecutive one-pot conditions combining three palladium-catalyzed reactions (Sonogashira, Heck and Suzuki-Miyaura reactions), a more efficient domino multicomponent method has been successfully developed to access a wide variety of 3-(diarylmethylene)oxindoles. Microwave irradiation and use of a silver salt were the most important factors to achieve high yields and stereoselectivity.

Palladium-catalyzed one-pot approach to 3-(Diarylmethylene)oxindoles from propiolamidoaryl triflate

3-(Diarylmethylene)oxindoles have been synthesized from propiolamidoaryl triflate utilizing a palladium-catalyzed one-pot reaction consisting of three successive reactions: Sonogashira, Heck, and Suzuki-Miyaura. This method allows for the production of a complex skeleton of 3-(diarylmethylene)oxindole from propiolamidoaryl triflate using a commercially available aryl iodide and arylboronic acid in a simple and efficient way with moderate yield and stereoselectivity.

Palladium-Catalyzed Tandem Approach to 3-(Diarylmethylene)oxindoles Using Microwave Irradiation

We developed a rapid and efficient microwave-assisted tandem reaction for the synthesis of 3-(diarylmethylene)oxindoles. Three palladium-catalyzed reactions (Sonogashira, Heck, and Suzuki-Miyaura reactions) were combined under microwave irradiation conditions to produce 3-(diarylmethylene)oxindoles from simple propiolamides, aryl iodides, and arylboronic acids. The addition of Ag3PO4 enhanced the yield and stereoselectivity of the tandem reaction significantly.

Room-temperature palladium-catalyzed intramolecular oxidative aminocarbonylation of vinylic C(sp2)-H bonds with amines and CO

A new, mild route to access 3-methyleneindolin-2-ones is presented that proceeds through a room-temperature, palladium-catalyzed intramolecular oxidative aminocarbonylation of alkenes with amines and CO. This method represents a new aminocarbonylation str

Room-Temperature Palladium-Catalyzed Intramolecular Oxidative Aminocarbonylation of Vinylic C(sp2)-H Bonds with Amines and CO

A new, mild route to access 3-methyleneindolin-2-ones is presented that proceeds through a room-temperature, palladium-catalyzed intramolecular oxidative aminocarbonylation of alkenes with amines and CO. This method represents a new aminocarbonylation str

Palladium-catalyzed oxidative arylation of trisubstituted olefin: An efficient synthesis of 3-(disubstituted)alkylidene-oxindoles

A palladium-catalyzed oxidative arylation of 3-(monosubstituted)alkylidene- oxindoles with arenes afforded 3-(disubstituted)alkylidene-oxindoles in good to moderate yields.

Synthesis of 3-(diarylmethylene)oxindoles via a palladium-catalyzed one-pot reaction: Sonogashira-heck-suzuki-miyaura combined reaction

A novel one-pot reaction for the synthesis of 3-(diarylmethylene)oxindoles is described. The reaction involves the successive combination of three palladium-catalyzed reactions (Sonogashira, Heck, and Suzuki-Miyaura reactions). This method enables the rapid synthesis of various 3-(diarylmethylene)oxindoles from simple propiolamides. The addition of silver salts dramatically enhanced the E/Z stereoselectivity of the reaction. Georg Thieme Verlag Stuttgart, New York.

Selective synthesis of 3-aryl quinolin-2(1H)-ones and 3-(1-arylmethylene) oxindoles involving a 2-fold arene C-H activation process

(Chemical Equation Presented) A novel and selective palladium-catalyzed C-H activation protocol has been developed for the synthesis of 3-aryl quinolin-2(1H)-ones and 3-(1-arylmethylene)oxindoles with use of PivOH as the switch. In the presence of Pd(OAc)