468068-39-5

Basic information

• Product Name: 6-Chloro-N-hydroxy-3-pyridinecarboximidamide
• Synonyms: 6-Chloro-N-hydroxy-3-pyridinecarboximidamide;6-Chloro-N-hydroxypyridine-3-carboxamidine;6-Chloro-N-hydroxypyridine-3-carboximidamide
• CAS NO: 468068-39-5
• Molecular Formula: C₆H₆ClN₃O
• Molecular Weight: 171.59
• Product Categories: pharmacetical
• Mol File: 468068-39-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-Chloro-N-hydroxy-3-pyridinecarboximidamide(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-N-hydroxy-3-pyridinecarboximidamide(468068-39-5)
• EPA Substance Registry System: 6-Chloro-N-hydroxy-3-pyridinecarboximidamide(468068-39-5)

Safety Data

• Hazardous Substances Data: 468068-39-5(Hazardous Substances Data)

Usage

Properties

1. Chemical Formula: $C6H5ClN4O$
2. Derivative: Derived from pyridinecarboximidamide
3. Functional Groups:
Chlorine atom (Cl)
Hydroxyl group (OH)
4. Potential Applications:
Medicinal chemistry
Pharmaceutical drug development
5. Unique Structure:
Presence of chlorine atom and hydroxyl group attached to the pyridine ring
6. Promise for Further Research:
Promising candidate for synthesis of novel compounds with potential therapeutic properties
7. Utility:
Useful in various chemical and biochemical processes in laboratory or industrial settings

Structure

Contains a chlorine atom and a hydroxyl group attached to the pyridine ring

Applications

Medicinal chemistry: Potential use in drug discovery and development
Pharmaceutical drug development: May serve as a precursor or intermediate in the synthesis of pharmaceuticals

Potential

Promising candidate for further research due to its unique structure and functional groups

Utility

Useful in various chemical and biochemical processes, both in laboratory and industrial settings, owing to its chemical properties and reactivity

Upstream product

• 33252-28-7 6-chloronicotinonitrile 

Downstream Products

• 1201594-74-2 4-[3-(6-chloropyridin-3-yl)-1,2,4-oxadiazol-5-yl]benzonitrile 

Relevant articles and documents

Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design

Indoleamine 2,3-dioxygenase-1 (IDO1) is a potential target for the next generation of cancer immunotherapies. We describe the development of two series of IDO1 inhibitors incorporating a N-hydroxy-thiophene-carboximidamide core generated by knowledge-based drug design. Structural modifications to improve the cellular activity and pharmacokinetic (PK) properties of the compounds synthesized, including extension of the side chain of the N-hydroxythiophene-2-carboximidamide core, resulted in compound 27a, a potent IDO1 inhibitor which demonstrated significant (51%) in vivo target inhibition on IDO1 in a human SK-OV-3 ovarian xenograft tumor mouse model. This strategy is expected to be applicable to the discovery of additional IDO1 inhibitors for the treatment of other diseases susceptible to modulation of IDO1.

PHARMACEUTICAL COMPOSITIONS AND THEIR METHODS OF USE

The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an α4β2 positive allosteric modulator, a method of using the same, and a related article of manufacture.

Discovery and structure-activity relationship of 3-aryl-5-aryl-1,2,4- oxadiazoles as a new series of apoptosis inducers and potential anticancer agents

We have identified 5-(3-chlorothiophen-2-yl)-3-(4-trifluoromethylphenyl)-1, 2,4-oxadiazole (1d) as a novel apoptosis inducer through our caspase- and cell-based high-throughput screening assay. Compound 1d has good activity against several breast and colorectal cancer cell lines but is inactive against several other cancer cell lines. In a flow cytometry assay, treatment of T47D cells with 1d resulted in arrest of cells in the G1 phase, followed by induction of apoptosis. SAR studies of Id showed that the 3-phenyl group can be replaced by a pyridyl group, and a substituted five-member ring in the 5-position is important for activity. 5-(3-Chlorothiophen-2-yl)-3-(5- chloropyridin-2-yl)-1,2,4-oxadiazole (41) has been found to have in vivo activity in a MX-1 tumor model. Using a photoaffinity agent, the molecular target has been identified as TIP47, an IGFII receptor binding protein. Therefore, our cell-based chemical genetics approach for the discovery of apoptosis inducers can identify potential anticancer agents as well as their molecular targets.