6-Chloro-N-hydroxy-3-pyridinecarboximidamide

Base Information

• Chemical Name: 6-Chloro-N-hydroxy-3-pyridinecarboximidamide
• CAS No.: 468068-39-5
• Molecular Formula: C6H6ClN3O
• Molecular Weight: 171.586
• Hs Code.: 2933399090
• Mol file: 468068-39-5.mol

Synonyms:6-Chloro-N-hydroxy-3-pyridinecarboximidamide;6-Chloro-N-hydroxypyridine-3-carboxamidine;6-Chloro-N-hydroxypyridine-3-carboximidamide

Chemical Property of 6-Chloro-N-hydroxy-3-pyridinecarboximidamide

Chemical Property:

• Boiling Point: 375.875oC at 760 mmHg
• Flash Point: 181.123oC
• PSA: 69.00000
• Density: 1.514g/cm3
• LogP: 1.52980

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-N-hydroxy-nicotinamidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Chloro-N-hydroxy-3-pyridinecarboximidamide

There total 1 articles about 6-Chloro-N-hydroxy-3-pyridinecarboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

6-chloronicotinonitrile (33252-28-7) → 6-chloro-N'-hydroxypyridine-3-carboximidamide (468068-39-5)

Guidance literature:

With hydroxylamine hydrochloride; potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃;

DOI:10.1021/jm0302602

Reference yield: 89.0%

4-cyanobenzoic Acid (619-65-8,333406-09-0) + 6-chloro-N'-hydroxypyridine-3-carboximidamide (468068-39-5) → 4-[3-(6-chloropyridin-3-yl)-1,2,4-oxadiazol-5-yl]benzonitrile (1201594-74-2)

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In ethyl acetate; at 80 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2009.09.114

Reference yield: 35.0%

3-bromo-4-fluoroaniline (656-64-4) + 6-chloro-N'-hydroxypyridine-3-carboximidamide (468068-39-5) → N-(3-bromo-4-fluorophenyl)-6-chloro-N'-hydroxypyridine-3-carboximidamide

Guidance literature:

6-chloro-N'-hydroxypyridine-3-carboximidamide; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 3h; Inert atmosphere;

3-bromo-4-fluoroaniline; In tetrahydrofuran; at 20 ℃; for 17h; Inert atmosphere;

DOI:10.1016/j.ejmech.2021.114043

upstream raw materials:

6-chloronicotinonitrile

Downstream raw materials:

4-[3-(6-chloropyridin-3-yl)-1,2,4-oxadiazol-5-yl]benzonitrile

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