468071-40-1Relevant academic research and scientific papers
Dihydropyrimidinones--a new class of anti-staphylococcal antibiotics.
Brands, Michael,Endermann, Rainer,Gahlmann, Reinhold,Krueger, Jochen,Raddatz, Siegfried
, p. 241 - 245 (2003)
We report the synthesis and pharmacological evaluation of new derivatives of natural dipeptide antibiotic TAN-1057 A, B. In the course of this program, we identified novel analogues of the natural product that display similar antibacterial activity and showed improved tolerability.
Toward a library synthesis of the natural dipeptide antibiotic TAN 1057 A,B
Aguilar, Nuria,Krueger, Jochen
, p. 469 - 474 (2007/10/03)
The natural dipeptide antibiotic TAN 1057 A,B represents a promising new antibiotic entity. In this communication we report a novel approach for the synthesis of TAN 1057 A,B analogs bearing variations in the β-arginine side chain. This approach involves a combination of liquid and solid phase methods and allows for a library synthesis of analogs of the natural product.
Novel antibiotics for the treatment of Gram-positive bacterial infections
Brands, Michael,Endermann, Rainer,Gahlmann, Reinhold,Krüger, Jochen,Raddatz, Siegfried,Stoltefu?, Ju?rgen,Belov, Vladimir N.,Nizamov, Shamil,Sokolov, Viktor V.,De Meijere, Armin
, p. 4246 - 4253 (2007/10/03)
The natural dipeptide antibiotic TAN 1057 A,B displays excellent antibacterial activity against staphylococci including methicillin resistant Staphylococcus aureus. However, the in vitro activity against additional Gram-positive strains, in particular pne
