468072-69-7Relevant academic research and scientific papers
Mechanistic insights into the palladiumII-catalyzed hydroxyalkoxylation of 2-allylphenols
Thiery, Emilie,Chevrin, Carole,Le Bras, Jean,Harakat, Dominique,Muzart, Jacques
, p. 1859 - 1862 (2007/10/03)
The Pd(OCOCF3)2/[(HOCH2CH 2NHCOCH2)2NCH2]2- catalyzed oxidation of o-allylphenol with H2O2 in water/methanol affords a syn and anti mixture of 2-(1,2-dihydroxypropyl)phenol and 2-(2-hydroxy-1-methoxypropyl)phenol. Mechanistic experiments and ESI-MS studies support a pathway wherein isomerization of the C=C bond followed by its epoxidation and oxirane opening led to the products. Recycling of the catalytic system led to gradual lost of activity.
