468072-82-4Relevant academic research and scientific papers
An efficient multikilogram synthesis of ABT-963: A selective COX-2 inhibitor
Kerdesky, Francis A. J.,Leanna, M. Robert,Zhang, Ji,Li, Wenke,Lallaman, John E.,Ji, Jianguo,Morton, Howard E.
, p. 512 - 517 (2006)
An efficient chemical process for the multikilogram synthesis of ABT-963 (3) is described. The potent and selective COX-2 inhibitor was prepared in four steps in 36% overall isolated yield from commercially available 3,4-difluoroaniline (4). The chemistry, which required no chromatography, involved a facile one-pot synthesis of the pyridazinone core, a selective alkoxylation, a high yielding Suzuki coupling, and a very efficient oxidation.
