468078-76-4

Upstream product

• 468078-68-4 1-(3-benzyloxy-1,6,8-trimethoxy-naphthalen-2-yl)-1-(3-hydroxymethyl-1,6,8-trimethoxy-naphthalen-2-yl)-methanone 
• 74-88-4 methyl iodide 
• 468078-48-0 3-benzyloxy-1,6,8-trimethoxy-naphthalene-2-carboxylic acid 3-bromo-4,5,7-trimethoxy-naphthalen-2-yl methyl ester 
• 468078-58-2 3-(tert-Butyl-dimethyl-silanyloxy)-1,6,8-trimethoxy-naphthalene-2-carboxylic Acid Methyl Ester 
• 468078-50-4 3-Benzyloxy-1,6,8-trimethoxy-naphthalene-2-carboxylic Acid 
• 468078-56-0 methyl 1,3-dihydroxy-6,8-dimethoxynaphthalene-2-carboxylate 
• 505052-96-0 3-Hydroxy-1,6,8-trimethoxy-naphthalene-2-carboxylic Acid Methyl Ester 

Relevant academic research and scientific papers

Process for the manufacture of hypoxyxylerone derivatives

The present invention relates to the total synthesis of hypoxyxylerone derivatives (formula I) and their biological activities. R1-R5 are as described in the description.

Synthetic Approach to Hypoxyxylerone, Novel Inhibitor of Topoisomerase I

(Equation Presented) A potential route to the topoisomerase I inhibitor hypoxyxylerone is demonstrated by a highly convergent synthesis of the penta(O-methyl) derivative. The key step in the approach is an anionic homo-Fries rearrangement, little used to