468096-22-2Relevant articles and documents
Design, synthesis, docking study and biological evaluation of novel thieno[2,3-d]-pyrimidine tethered 1,2,3-triazole scaffolds
Jonnalagadda, Sreekantha B.,Maddila, Suresh,Nagaraju, Kerru,Suryanarayana, Kotyada
, (2021/10/27)
The evolution of Click chemistry led to the expansion of a contemporary library of 1,2,3-triazole-thieno[2,3-d]-pyrimidine derivatives which were synthesized via Cu-catalyzed 1,3-dipolar cycloaddition reaction involving propargylated thieno[2,3-d]-pyrimidine and various aromatic azides in an equal ratio of solvent system (dichloromethane and water (1:1 v/v)) at room temperature. The newly synthesized target molecules were characterized and confirmed through various spectral analyses such as 1H NMR, 13C NMR and HR-MS. All the target products were evaluated for their antioxidant scavenging ability through DPPH, NO, and ABTS radical methods. The molecule 7j exhibited promising antioxidant activity against DPPH scavenging with an IC50 value of 8.161 μM, as compared to the standard drug ascorbic acid (IC50 = 3.073 μM). The nature and position of the groups substituted on the aryl ring were explored using structure-activity relationship (SAR) analysis.
