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31891-06-2

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31891-06-2 Usage

Chemical Properties

Brown Solid

Uses

Ethyl 2-aminothiophene-3-carboxylate is used as an organic chemical synthesis intermediate.

Check Digit Verification of cas no

The CAS Registry Mumber 31891-06-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,8,9 and 1 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 31891-06:
(7*3)+(6*1)+(5*8)+(4*9)+(3*1)+(2*0)+(1*6)=112
112 % 10 = 2
So 31891-06-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H9NO2S/c1-2-10-7(9)5-3-4-11-6(5)8/h3-4H,2,8H2,1H3

31891-06-2 Well-known Company Product Price

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  • Alfa Aesar

  • (H61559)  Ethyl 2-aminothiophene-3-carboxylate, 98%   

  • 31891-06-2

  • 25g

  • 713.0CNY

  • Detail
  • Alfa Aesar

  • (H61559)  Ethyl 2-aminothiophene-3-carboxylate, 98%   

  • 31891-06-2

  • 100g

  • 2562.0CNY

  • Detail

31891-06-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Ethyl 2-aminothiophene-3-carboxylate

1.2 Other means of identification

Product number -
Other names 2-amino-3-ethoxycarbonylthiophene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:31891-06-2 SDS

31891-06-2Relevant articles and documents

α,α′-N-boc-substituted Bi- and terthiophenes: Fluorescent precursors for functional materials

Dong, Yanmei,Navarathne, Daminda,Bolduc, Andreanne,McGregor, Nicholas,Skene

, p. 5429 - 5433 (2012)

Fluorescent α,α′-diamide substituted bi- and terthiophene derivatives were prepared by Stille and Suzuki couplings. Their one-pot deprotection and coupling with 2-thiophene carboxaldehyde led to stable conjugated azomethines. These exhibited electrochromic properties, and they were used to fabricate a working electrochromic device.

Synthesis of thienopyridinones via hydrazide-alkyne cyclization

Balci, Metin,Cokol, Nalan Korkmaz,Dengiz, Cagatay,Erden, Kübra,Gunay, Furkan Melih

supporting information, (2020/04/08)

A novel and efficient method for the synthesis of thieno[3,2-c]pyridinones have been developed. The synthetic strategy relies on the synthesis of halothiophene esters utilized as substrates for subsequent Sonogashira cross-coupling reactions. Hydrazinolysis of corresponding esters and following hydrazide-alkyne ring closure transformations resulted in target thienopyridinones in good yields. It is also shown that pure hydrazine monohydrate is required to facilitate the hydrazide formations.

A Thieno[2,3- d]pyrimidine Scaffold Is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor

Fyfe, Tim J.,Zarzycka, Barbara,Lim, Herman D.,Kellam, Barrie,Mistry, Shailesh N.,Katrich, Vsevolod,Scammells, Peter J.,Lane, J. Robert,Capuano, Ben

, p. 174 - 206 (2018/05/14)

Recently, a novel negative allosteric modulator (NAM) of the D2-like dopamine receptors 1 was identified through virtual ligand screening. This ligand comprises a thieno[2,3-d]pyrimidine scaffold that does not feature in known dopaminergic ligands. Herein, we provide pharmacological validation of an allosteric mode of action for 1, revealing that it is a NAM of dopamine efficacy and identify the structural determinants of this allostery. We find that key structural moieties are important for functional affinity and negative cooperativity, while functionalization of the thienopyrimidine at the 5- and 6-positions results in analogues with divergent cooperativity profiles. Successive compound iterations have yielded analogues exhibiting a 10-fold improvement in functional affinity, as well as enhanced negative cooperativity with dopamine affinity and efficacy. Furthermore, our study reveals a fragment-like core that maintains low μM affinity and robust negative cooperativity with markedly improved ligand efficiency.

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