4681-11-2

Upstream product

• 93048-09-0 2,3,6-Trichlorobenzohydroximoyl chloride 
• 886967-66-4 ethyl 3-(2,3,6-trichlorophenyl)-4,5-dihydroisoxazole-5-carboxylate 
• 886967-71-1 3-(2,3,6-trichlorophenyl)-4,5-dihydroisoxazole-5-carboxylic acid 

Downstream Products

• 86225-73-2 3-chloro-2,6-difluorobenzonitrile 

Relevant academic research and scientific papers

New fragmentation of 2-isoxazoline-5-carboxylic acid chlorides

A novel base promoted degradation of 3-aryl-2-isoxazoline-5-carboxylic acid chlorides to aryl nitriles has been discovered.

Process for preparing aromatic nitriles

Aromatic nitriles having the general formula (I): wherein: - Rrepresents the hydrogen atom., a fluorine, chlorine, bromine or iodine atom, a (C1-C5)-alkoxy group, a carboxy group, a (C1-C5)-carboxy-alkyl, or an aryl group selected from among phenyl, halo-phenyl, phenyl-ether or nitrile; - R' and R"either equal to, or different from, each other, represent the hydrogen atom or a fluorine, chlorine, bromine or iodine atom; are obtained by reacting an organic or inorganic ammonium salt (III):, , NH4(+) X(-) (III), , and an aromatic trichloromethyl derivative having formula (II): wherein R, R' and R" have the above set forth meaning, with the exception that when R in formula (I) represents the nitrile group, the corresponding R group in formula (II) represents the trichloromethyl group, operating in the presence of a catalyst consisting of a metal oxide or a metal salt. The process makes it possible high yields and high selectivities to the useful reaction product to be obtained.

Process for producing polychlorobenzonitrile

A process for producing polychlorobenzonitrile having chlorine atoms at the 2,6-position by ammoxidation of toluene derivative having chlorine atoms at the 2,6-position with a gas containing ammonia and oxygen in vapor phase in the presence of a catalyst, characterized in that bromine and/or a bromine-containing compound is added to the reaction system.

Process for producing 2,6-difluorobenzonitrile

A process for producing 2,6-difluorobenzonitrile comprises reducing a chloro fluorobenzonitrile selected from 3-chloro-2,6-difluorobenzonitrile, 3,5-dichloro-2,6-difluorobenzonitrile or a mixture thereof by hydrogen gas in the presence of a palladium or platinum catalyst at a temperature of 0° to 200° C.